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Synthesis of High-Purity Basic Bismuth(III) Succinate as a Pharmaceutical Substance

  • Inorganic Synthesis and Industrial Inorganic Chemistry
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Abstract

Reactions of solid trihydroxopentaoxohexabismuth(III) pentanitrate trihydrate [Bi6O5(OH)3](NO3)5·3H2O and monoclinic bismuth oxide α-Bi2O3 with a succinic acid solution were studied with the aim of preparing a pharmaceutical substance, basic bismuth succinate С2Н4(СООBiO)2, meeting high purity requirements concerning the content of impurity metals. A procedure for preparing basic bismuth(III) succinate was suggested; it involves hydrolytic treatment of a process solution of bismuth in nitric acid to obtain high-purity [Bi6O5(OH)3](NO3)5·3H2O, its treatment with a NaOH solution to obtain finely crystalline α-Bi2O3, and the subsequent reaction of bismuth oxide with a succinic acid solution. The product composition was confirmed by X-ray diffraction, chemical analysis, IR and Raman spectroscopy, and thermal gravimetric analysis; the content of impurity metals was determined by the atomic absorption method.

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Notes

  1. Pharmacopee Francaise. Bismuth (sous-succinate de).

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ACKNOWLEDGMENTS

The authors are grateful to the Center for Shared Use High Technologies and Nanosystems Analytics at the Novosibirsk State University for the opportunity to use the equipment for recording the Raman spectra.

Funding

The study was performed in accordance with the thematic plan of the Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences (121032500064-8) and Novosibirsk State Technical University (TP-KhKhT-1_21).

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Authors and Affiliations

  1. Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences, 630128, Novosibirsk, Russia

    E. V. Timakova, E. I. Bun’kova, L. I. Afonina & Yu. M. Yukhin

  2. Novosibirsk State Technical University, 630073, Novosibirsk, Russia

    E. V. Timakova, E. I. Bun’kova & L. I. Afonina

  3. Rzhanov Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    V. A. Volodin

  4. Novosibirsk State University, 630090, Novosibirsk, Russia

    V. A. Volodin

Authors
  1. E. V. Timakova
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  2. E. I. Bun’kova
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  3. L. I. Afonina
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  4. Yu. M. Yukhin
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  5. V. A. Volodin
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Contributions

E.V. Timakova: development of the concept of the study and experimental procedure, collection, analysis, and interpretation of the results, and participation in manuscript preparation; E.I. Bun’kova: all the syntheses, collection of literature data, preparation of literature review, and participation in manuscript preparation; L.I. Afonina: studies of the chemical composition of the samples obtained and participation in processing and interpretation of the results and in manuscript preparation; Yu.M. Yukhin: consulting on planning of enlarged laboratory trials and their guidance, participation in interpretation of the results, and major contribution to writing the section on the procedure for preparing basic bismuth succinate; V.A. Volodin: Raman and IR studies of the samples and interpretation of the spectroscopic data obtained.

Corresponding author

Correspondence to E. V. Timakova.

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The authors declare that they have no conflict of interest.

Additional information

Translated from Zhurnal Prikladnoi Khimii, No. 7, pp. 857–866, January, 2021 https://doi.org/10.31857/S0044461821070069

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Timakova, E.V., Bun’kova, E.I., Afonina, L.I. et al. Synthesis of High-Purity Basic Bismuth(III) Succinate as a Pharmaceutical Substance. Russ J Appl Chem 94, 911–919 (2021). https://doi.org/10.1134/S1070427221070077

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  • DOI: https://doi.org/10.1134/S1070427221070077

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