Abstract
Rheological behavior of chitosan succinimide in water-glycerol mixed solvent was studied. Partial replacement of water by glycerol leads to an increase in the complex viscosity of the polymer in solution, to the formation of the network of intermolecular linkages and transition of the system to the gel state at a lower polymer concentration, to a decrease in the polymer concentration in the solution at which the storage modulus becomes higher than the loss modulus, and to an increase in the relaxation time. The systems formed in the process exhibit the viscosity characteristics stable in time and allow preparation of water-insoluble gel-like materials suitable as a base for soft drug forms.
Similar content being viewed by others
References
Murav’ev, I.A., Tekhnologiya lekarstv (Drug Technology), Moscow: Meditsina, 1980, 3rd ed., vol. 2.
Marchenko, L.G., Rusak, A.V., and Smekhova, I.E., Tekhnologiya myagkikh lekarstvennykh form (Technology of soft drug forms), St. Petersburg: SpetsLit, 2004.
Karadag, E., Saraydin, D., Centinkaya, S., and Guven, O., Biomaterials, 1996, vol. 17, pp. 67–70.
Akala, E.O., Kopeckova, P., and Kopecek, J., Biomaterials, 1998, vol. 19, pp. 1037–1047.
Blanco, M.D., Garcia, O., Trigo, R.M., Teijon, J.M., and Katime, I., Biomaterials, 1996, vol. 17, pp. 1061–1067.
Shchukin, E.D., Pertsov, A.V., and Amelina, E.A., Kolloidnaya khimiya (Colloid Chemistry), Moscow: Vysshaya Shkola, 2004, 3rd ed.
Sivakumar, M. and Paduranga Rao, K., J. Appl. Polym. Sci., 2002, vol. 83, no. 14, pp. 3045–3054.
Yin, Y., Yang, Y., and Xu, H., J. Appl. Polym. Sci., 2002, vol. 83, no. 13, pp. 2835–2842.
Hoffman, A.S., Polymers in Medicine and Surgery, Kronenthal, R.L., Oser, Z., and Martin, E., Eds., New York: Plenum, 1975, pp. 33–44.
Hydrogels in Medicine and Pharmacy, Peppas, N.A., Ed., Boca Raton, Florida: CRC, 1987, vol. 3.
Bell, C.L. and Peppas, N.A., Adv. Polym. Sci., 1995, vol. 122, pp. 125–176.
Chuang, W.Y., Young, T.H., Yao, C.H., and Chiu, W.Y., Biomaterials, 1999, vol. 20, pp. 1479–1487.
Park, H. and Park, K., Hydrogels and Biodegradable Polymers for Bioapplications, Ottenbrite, R.M., Huang, S.J., and Park, K., Eds., vol. 627 of ACS Symp. Ser., Washington, DC: ACS, 1996, pp. 2–10.
Rabea, E.I., Badawy, M.E.T., and Stevens, C.V., Biomacromolecules, 2003, no. 4, pp. 1457–1465.
Papkov, S.P., Studneobraznoe sostoyanie polimerov (Gel-Like State of Polymers), Moscow: Khimiya, 1974.
Tanaka, T., Encyclopedia of Polymer Science and Engineering, Klingsberg, A. and Piccinini, P., Eds., New York: Wiley, 1985, vol. 7.
Rogovina, L.Z., Vasil’ev, V.G., and Braudo, E.E., Polym. Sci., Ser. C, 2008, vol. 50, no. 1, pp. 85–92.
Nijenhuis, K. te, Adv. Polym. Sci., 1997, vol. 130, pp. 1–252.
Clark, A.H. and Ross-Murhy, S.B., Adv. Polym. Sci., 1987, vol. 83, pp. 57–192.
Ross-Murhy, S.B., Polymer Gels, Rossi, D. De, Kajiwara, K., Osada, Y., and Yamauchi, A., Eds., New York: Plenum, 1991, pp. 21–39.
Shchegolikhina, O.I., Vasil’ev, V.G., Rogovina, L.Z., Levin, V.Yu., Zhdanov, A.A., and Slonimskii, G.L., Vysokomol. Soedin., Ser. A, 1991, vol. 33, no. 11, pp. 2370–2375.
Stadler, R., Macromolecules, 1988, vol. 21, no. 1, pp. 121–129.
Suresh, S., Painter, P.C., and Coleman, M.M., Polymer, 1999, vol. 40, no. 17, pp. 4853–4863.
Mochalova, A.E., Smirnova, L.A., Semchikov, Yu.D., Kir’yanov, K.V., Drozdov, Y.N., and Prusakova, I.I., Polym. Sci., Ser A, 2005, vol. 47, no. 6, pp. 614–621.
Skorikova, E.E., Kalyuzhnaya, R.I., Kotova, S.L., Ageev, E.P., Zezin, A.B., Kabanov, V.A., Vikhoreva, G.A., and Gal’braikh, L.S., Polym. Sci., Ser. A, 1996, vol. 38, no. 1, pp. 49–53.
Alekseev, V.L., Kel’berg, E.A., Bronnikov, S.V., and Evmenenko, G.A., Polym. Sci., Ser. B, 2001, vol. 43, nos. 9–10, pp. 281–284.
Litmanovich, E.A., Orleneva, A.P., Korolev, B.A., Kasaikin, V.A., and Kulichikhin, V.G., Polym. Sci., Ser. A, 2000, vol. 42, no. 6, pp. 689–690.
Tager, A.A., Dreval’, V.E., Kurbanaliev, M., Lutskii, M.S., Berkovits, N.E., Granovskaya, I.M., and Charikova, T.A., Vysokomol. Soedin., Ser. A, 1968, vol. 10, no. 9, pp. 2044–2057.
Tager, A.A., Dreval’, V.E., Botvinnik, G.O., Kenina, S.B., Novitskaya, V.I., Sidorova, L.K., and Usol’tseva, T.A., Vysokomol. Soedin., Ser. A, 1972, vol. 14, no. 6, pp. 1381–1390.
Ilyin, S.O., Kulichikhin, V.G., and Malkin, A.Ya., Polym. Sci., Ser. A, 2013, vol. 55, no. 8, pp. 503–506.
Bazunova, M.V., Valiev, D.R., Chernova, V.V., and Kulish, E.I., Polym. Sci., Ser. A, 2015, vol. 57, no. 5, pp. 675–680.
Ferry, J.D., Viscoelastic Properties of Polymers, New York: Wiley, 1980.
Bazunova, M.V., Shurshina, A.S., Chernova, V.V., and Kulish, E.I., Russ. J. Phys. Chem. B, 2016, vol. 10, no. 6, pp. 1014–1021.
Mironov, A.V., Vikhoreva, G.A., Kil’deeva, N.R., and Uspenskii, S.A., Polym. Sci., Ser. B, 2007, vol. 49, nos. 1–2, pp. 15–17.
Vikhoreva, G.A., Rogovina, S.Z., Pchelko, O.M., and Gal’braikh, L.S., Polym. Sci., Ser. B, 2001, vol. 43, nos. 5–6, pp. 166–170.
Abramov, A.Y., Kozyreva, E.V., and Shipovskaya, A.B., Eur. J. Natural History, 2013, no. 1, pp. 30–35.
Korchagina, E.V. and Philippova, O.E., Biomacromolecules, 2010, vol. 11, no. 12, pp. 3457–3466.
Zamani, A. and Taherzadeh, M.J., Bio Resources, 2010, vol. 5, no. 3, pp. 1554–1564.
Kulish, E.I., Chernova, V.V., Volodina, V.P., and Kolesov, S.V., Polym. Sci., Ser. A, 2015, vol. 57, no. 5, pp. 508–514.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lazdin, R.Y., Chernova, V.V., Bazunova, M.V. et al. Rheological Properties of Chitosan Succinimide in Water-Glycerol Mixed Solvent. Russ J Appl Chem 92, 50–56 (2019). https://doi.org/10.1134/S1070427219010075
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1070427219010075