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Impacts of Chemical Variables on the Encapsulated Corticoids in Poly-ε-caprolactone Nanoparticles and Statistical Biological Analysis

  • Macromolecular Compounds and Polymeric Materials
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Abstract

The goal of this research is to evaluate the impact of different parameters on corticosteroids entrapment in biocompatible poly-ε-caprolactone nanoparticles. These findings provide better insight on the designing carriers for drugs. Nanocapsules were synthesized by interfacial deposition and their morphology was determined by SEM. Drug entrapment efficiency and particle size distribution were assayed by HPLC and DLS, respectively. The samples were assessed for cytotoxicity using MTT reduction assay. The anti-inflammatory effect of the formulated drug was determined by induction of inflammation in treated as well as native laboratory animals. Statistical analysis of the data was performed using SPSS 18.0.

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Authors and Affiliations

  1. Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran

    R. Amiri Dehkharghani, M. Zandi Doust & H. Hossein Shahi

  2. Department of Influenza Unit, Pasteur Institute, Tehran, Iran

    M. Tavassoti Kheiri

Authors
  1. R. Amiri Dehkharghani
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  2. M. Zandi Doust
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  3. M. Tavassoti Kheiri
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  4. H. Hossein Shahi
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Correspondence to R. Amiri Dehkharghani.

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The text was submitted by the authors in English.

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Amiri Dehkharghani, R., Zandi Doust, M., Tavassoti Kheiri, M. et al. Impacts of Chemical Variables on the Encapsulated Corticoids in Poly-ε-caprolactone Nanoparticles and Statistical Biological Analysis. Russ J Appl Chem 91, 1165–1171 (2018). https://doi.org/10.1134/S1070427218070157

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  • DOI: https://doi.org/10.1134/S1070427218070157

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