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Synthesis, isolation, and purification of benzylpenicillin β-diethylaminoethyl ester hydroiodide

  • Organic Synthesis and Industrial Organic Chemistry
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Abstract

Processes of synthesis, isolation, and purification of benzylpenicillin β-diethylaminoethyl ester hydroiodide were studied. The optimal conditions of benzylpenicillin esterification with chloroethyldiethylamine in dimetylformamide and acetonitrile were found. Processes for isolation of the target product were developed and its physicochemical properties were studied. Product stabilization conditions providing a stable pH value in solutions of benzylpenicillin β-diethylaminoethyl ester hydroiodide were found.

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Authors and Affiliations

  1. Fine Chemicals, Limited-Liability Research-and-Production Company, St. Petersburg, Russia

    E. A. Savel’ev, I. M. Volkova & A. L. Kovalevskaya

Authors
  1. E. A. Savel’ev
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  2. I. M. Volkova
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  3. A. L. Kovalevskaya
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Additional information

Original Russian Text © E.A. Savel’ev, I.M. Volkova, A.L. Kovalevskaya, 2010, published in Zhurnal Prikladnoi Khimii, 2010, Vol. 83, No. 7, pp. 1124–1131.

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Savel’ev, E.A., Volkova, I.M. & Kovalevskaya, A.L. Synthesis, isolation, and purification of benzylpenicillin β-diethylaminoethyl ester hydroiodide. Russ J Appl Chem 83, 1230–1237 (2010). https://doi.org/10.1134/S1070427210070128

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  • DOI: https://doi.org/10.1134/S1070427210070128

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