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Synthesis and Phosphonylation of 6-Amino-4-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitriles

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Abstract

A series of 6-amino-4-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitriles was synthesized, further reaction of which with dimethyl chloroethynylphosphonate yielded a series of new dimethyl (8-cyano-7-aryl-5-thioxo-5,6-dihydroimidazo[1,2-c]pyrimidin-2-yl)phosphonates.

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Funding

This work was financially supported by the Russian Science Foundation (grant no. 23-13-00224, https://rscf.ru/project/23-13-00224/) using the equipment of the Engineering Center of the St. Petersburg State Institute of Technology.

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Authors and Affiliations

  1. St. Petersburg State Chemical and Pharmaceutical University, 197022, St. Petersburg, Russia

    N. A. Nosova

  2. St. Petersburg State Institute of Technology (Technical University), 190013, St. Petersburg, Russia

    E. D. Fatuev, A. S. Krylov & D. M. Egorov

  3. St. Petersburg Federal Research Center of the Russian Academy of Sciences, 199178, St. Petersburg, Russia

    A. S. Krylov & D. M. Egorov

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  1. N. A. Nosova
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  2. E. D. Fatuev
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Correspondence to D. M. Egorov.

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Nosova, N.A., Fatuev, E.D., Krylov, A.S. et al. Synthesis and Phosphonylation of 6-Amino-4-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitriles. Russ J Gen Chem 93, 3081–3088 (2023). https://doi.org/10.1134/S1070363223120071

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