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Interaction of Chitosan with Anionic Liquid Liposomes: Reversibility of Structural Rearrangements in Lipid Bilayer

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Abstract

Reversibility of structural rearrangements in a liquid liposomal membrane upon electrostatic adsorption/desorption of the cationic polymer (chitosan) has been studied. The polycation can be completely removed from the lipid membrane via addition of an excess of polyacrylic acid forming more stable electrostatic complex with chitosan. Removal of chitosan has resulted in complete recovery of the original lipid distributions in lateral and transmembrane directions as well as intervesicular lipid exchange.

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Funding

This study was carried out within the project “Modern Problems of Chemistry and Physical Chemistry of Macromolecular Compounds” (State Assignment no. АААА-А21-121011990022-4).

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Authors and Affiliations

  1. Lomonosov Moscow State University, 119991, Moscow, Russia

    A. A. Efimova, T. A. Abramova, A. S. Popov & T. E. Grokhovskaya

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  1. A. A. Efimova
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  2. T. A. Abramova
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  3. A. S. Popov
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  4. T. E. Grokhovskaya
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Correspondence to A. A. Efimova.

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Efimova, A.A., Abramova, T.A., Popov, A.S. et al. Interaction of Chitosan with Anionic Liquid Liposomes: Reversibility of Structural Rearrangements in Lipid Bilayer. Russ J Gen Chem 92, 2429–2435 (2022). https://doi.org/10.1134/S1070363222110275

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  • DOI: https://doi.org/10.1134/S1070363222110275

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