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Effect of glycol chitosan on functional and structural properties of anionic liposomes

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Moscow University Chemistry Bulletin Aims and scope

Abstract

The possibility of using glycol chitosan to obtain stabilized liposome containers for doxorubicin delivery is demonstrated. The dissociation constants of the liposome complexes with glycol chitosan (3.4 × 10–4 and 1.10 × 10–5 depending on the aggregation state of the liposomes) are determined. It is shown that the formation of liposome complexes with glycol chitosan has a significant prolongation effect on the release of doxorubicin from the liposomes at pH 7.4.

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Authors and Affiliations

  1. Department of Chemistry, Moscow State University, Moscow, 119991, Russia

    I. M. Deygen & E. V. Kudryashova

Authors
  1. I. M. Deygen
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  2. E. V. Kudryashova
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Correspondence to I. M. Deygen.

Additional information

Original Russian Text © I.M. Deygen, E.V. Kudryashova, 2016, published in Vestnik Moskovskogo Universiteta. Khimiya, 2016, No. 3, pp. 154–159.

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Deygen, I.M., Kudryashova, E.V. Effect of glycol chitosan on functional and structural properties of anionic liposomes. Moscow Univ. Chem. Bull. 71, 167–171 (2016). https://doi.org/10.3103/S0027131416030044

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  • DOI: https://doi.org/10.3103/S0027131416030044

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