Abstract
A method for the synthesis of new fused derivatives of 4-(fur-2-yl)pyrano[4,3-b]pyridines was developed by hydrolysis of 2-chloro-4-(2-furyl)-7,7-dimethyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carbonitrile, its further reaction with hydrazine hydrate and thioglycolic acid. The direction of electrophilic substitution in the pyridine ring was studied.
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REFERENCES
Souza, B.C., Oliveira, T.B., Aquino, T.M., De Lima, M.C., Pitta, I.R., Galidino, S.L., Lima, E.O., Gonclaves, T.S., Militao, G.C., Scotti, M.T., and Mendonca, F.J.Jr., Acta Pharm., 2012, vol. 62, no. 2, p. 221. https://doi.org/10.2478/v10007-012-0017-v
Srivastava, S.K., Tripathi, R.P., and Ramachandran, R., J. Biol. Chem., 2005, vol. 280, p. 30273. https://doi.org/10.1074/jbc.M502155200
Yamada, N., Kadowaki, S., Takahashi, K., and Umeza, K., Biochem. Pharmacol., 1992, vol. 44, p. 1211. https://doi.org/10.1016/0006-2952(92)90387-X
Ahmad, S., J. Nat. Prod., 1984, vol. 47, p. 391. https://doi.org/10.1021/np50032a035
Kolokythas, G., Pouli, N., Marakos, P., Pratsinis, H., and Kletsas, D., Eur. J. Med. Chem., 2006, vol. 41, p. 71. https://doi.org/10.1016/j.ejmech.2005.10.011
Ukawa, K., Ishiguro, T., Kuriki, H., and Nohara, A., Chem. Pharm. Bull., 1985, vol. 33, p. 4432. https://doi.org/10.1248/cpb.33.4432
Webber, L.G., Patent 7202648, 1979; C. A., 1980, vol. 92, 35997q.
Buchanan, J.G., Graven, D.A., Wighmtan, R.H., and Harnden, M., J. Chem. Soc. Perkin Trans., 1991, p. 195. https://doi.org/10.1039/P19910000195
Munchhof, M.J. and Sobolev-Jaynes, S.B., Patent WO 99.1999.24.440; C. A., 1999, vol. 131, 5266z.
Dabaeva, V.V., Bagdasaryan, M.R., Paronikyan, E.G., Tamazyan, R.A., Ayvazyan, A.G., and Dashyan, Sh.Sh., Russ. J. Gen. Chem., 2019, vol. 89, no. 12, p. 2364. https://doi.org/10.1134/S1070363219120065
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Dabaeva, V.V., Baghdasaryan, M.R., Barkhudaryants, I.M. et al. Synthesis of New Fused Derivatives of 4-(Fur-2-yl)pyrano[4,3-b]pyridines. Russ J Gen Chem 92, 1686–1691 (2022). https://doi.org/10.1134/S1070363222090109
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DOI: https://doi.org/10.1134/S1070363222090109