Abstract
Synthesis of some new N-{5-[(1H-benzo[d]imidazol-1-yl)methyl]isoxazol-3-yl}benzamide hybrids is presented herein. The in vitro anti-cancer activity of the synthesized compounds against four human cancer cell lines A549 (lung), HeLa (cervical), IMR-32 (neuroblast), and HEK-293 (embryonic kidney) has been tested. Four products have been determined to be active against all the cell lines. The compound N-{5-[(1H-benzo[d]imidazol-1-yl)methyl]isoxazol-3-yl}-3,5-dimethoxybenzamide has been characterized by significant anti-proliferative efficiency towards all tested cancer cells compared to the standard.
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ACKNOWLEDGMENTS
The authors are thankful to the Department of Chemistry, Chaitanya Deemed to be University for providing Laboratory facilities and Department of Biotechnology, Chaitanya Deemed to be University for their support in anticancer activity.
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Pandiri, M., Nukala, S.K., Swamy, T.N. et al. Design, Synthesis, and Anticancer Activity of Some New N-{5-[(1H-Benzo[d]imidazol-1-yl)methyl]isoxazol-3-yl}benzamide Hybrids. Russ J Gen Chem 91, 2320–2326 (2021). https://doi.org/10.1134/S1070363221110207
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DOI: https://doi.org/10.1134/S1070363221110207