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Synthesis, Biological Activity, and Crystal Structure of N,N-Diethyl-2-{[7-methoxy-4-(phenylamino)quinazolin-6-yl]oxy}acetamide Derivatives

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Abstract

A number of novel 4-aminoquinazoline derivatives has been synthesized by four-step synthesis. Structures of the synthesized compounds have been characterized by IR and 1H NMR spectra, element analysis, and single crystal X-ray diffraction. Biological activity of the products has been tested and most of those are characterized by potential antitumor activity against MKN45 cell line. Two compounds exhibit significant inhibitory activity higher than that of Gefitinib used as the positive control. Preliminary structure-activity relationship is considered.

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Funding

This work was supported financially by the Natural Science Foundation of Liaoning Province (NO. 20180550016), the Scientific Research Foundation of the Education Department of Liaoning Province (NO. LJGD2020015).

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Authors and Affiliations

  1. Liaoning Province Professional and Technical Innovation Center for Fine Chemical Engineering of Aromatics Downstream, School of Petrochemical Engineering, Shenyang University of Technology, Liaoyang, 111003, Liaoning, China

    Xiao Han, Zhi-qiang Cai & Ling Hou

  2. Shandong Center for Food and Drug Evaluation and Inspection, 250101, Shandong, China

    Li-hua Wu

  3. Key Laboratory for Chemical Drug Research of Shandong Province, Instiitute of Phamaceutical Sciences of Shandong Province, 250101, Shandong, China

    Shuai Li

Authors
  1. Xiao Han
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  2. Zhi-qiang Cai
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  3. Li-hua Wu
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  4. Ling Hou
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  5. Shuai Li
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Corresponding authors

Correspondence to Li-hua Wu or Ling Hou.

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Han, X., Cai, Zq., Wu, Lh. et al. Synthesis, Biological Activity, and Crystal Structure of N,N-Diethyl-2-{[7-methoxy-4-(phenylamino)quinazolin-6-yl]oxy}acetamide Derivatives. Russ J Gen Chem 91, 2286–2291 (2021). https://doi.org/10.1134/S1070363221110165

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