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Synthesis of Ethyl 4-[5-Aryl-3-hydroxy-4-(4-chlorobenzoyl)-2-oxo-2,3-dihydro-1H-pyrrol-1-yl]benzoates

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Abstract

The reaction of (4-chlorobenzoyl)pyruvic acid methyl ester with a mixture of aromatic aldehyde and 4-aminobenzoic acid ethyl ester in glacial acetic acid afforded ethyl 4-[5-aryl-3-hydroxy-2-oxo-4-(4-chlorobenzoyl)-2,5-dihydro-1H-pyrrol-1-yl]benzoates.

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Funding

This work was financially supported by the Ministry of Education and Science of Russia using the equipment of the Analytical Center of the St. Petersburg Chemical and Pharmaceutical University of the Ministry of Health of Russia (agreement no. 075-15-2021-685 from July 26, 2021).

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Authors and Affiliations

  1. Perm Pharmaceutical Academy, 614990, Perm, Russia

    V. L. Gein, D. A. Naif & E. V. Pastukhova

  2. St. Petersburg State University of Chemistry and Pharmacy, 197376, St. Petersburg, Russia

    I. P. Yakovlev

Authors
  1. V. L. Gein
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  2. D. A. Naif
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  3. E. V. Pastukhova
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  4. I. P. Yakovlev
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Correspondence to V. L. Gein.

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No conflict of interest was declared by the authors.

Additional information

Translated from Zhurnal Obshchei Khimii, 2021, Vol. 91, No. 11, pp. 1674–1678 https://doi.org/10.31857/S0044460X21110044.

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Gein, V.L., Naif, D.A., Pastukhova, E.V. et al. Synthesis of Ethyl 4-[5-Aryl-3-hydroxy-4-(4-chlorobenzoyl)-2-oxo-2,3-dihydro-1H-pyrrol-1-yl]benzoates. Russ J Gen Chem 91, 2151–2154 (2021). https://doi.org/10.1134/S1070363221110049

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  • DOI: https://doi.org/10.1134/S1070363221110049

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