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Synthesis and Chromatographic Analysis of the Neuroprotective Agent Mafedine and Related Compounds

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Abstract

A procedure for the synthesis of 2-anilino-6-hydroxy-3-phenylpyrimidin-4(3H)-one (mafedine) without using alkali metal ethoxides has been developed and optimized. Mafedine-related compounds that can be formed as possible impurities have been prepared, and conditions for joint determination of these impurities by HPLC with spectrophotometric detection have been found. The structure of the mafedine decomposition product in solution has been identified by HPLC-ESI/MS.

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Funding

Optimization of the synthesis of compound 1 and the syntheses of 4–6 were carried out in the framework of state assignment no. AAAA-A20-120121790030-8. The analytical part of the study was performed using the facilities of the Analytical Center at the St. Petersburg Chemical Pharmaceutical University (Ministry of Health of the Russian Federation) according to project nos. 075-15-2021-685 and 112-2019-0003 under financial support by the Ministry of Science and Higher Education of the Russian Federation.

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Authors and Affiliations

  1. St. Petersburg State Chemical Pharmaceutical University, 197376, St. Petersburg, Russia

    N. Yu. Sipkina, V. N. Yuskovets, N. M. Chernov & I. P. Yakovlev

  2. St. Petersburg State University, 198504, St. Petersburg, Russia

    G. L. Starova

Authors
  1. N. Yu. Sipkina
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  2. V. N. Yuskovets
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  3. N. M. Chernov
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  4. G. L. Starova
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  5. I. P. Yakovlev
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Corresponding author

Correspondence to N. M. Chernov.

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No conflict of interest was declared by the authors.

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Translated from Zhurnal Obshchei Khimii, 2021, Vol. 91, No. 9, pp. 1375–1381 https://doi.org/10.31857/S0044460X21090080.

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Sipkina, N.Y., Yuskovets, V.N., Chernov, N.M. et al. Synthesis and Chromatographic Analysis of the Neuroprotective Agent Mafedine and Related Compounds. Russ J Gen Chem 91, 1661–1666 (2021). https://doi.org/10.1134/S1070363221090085

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  • DOI: https://doi.org/10.1134/S1070363221090085

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