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Synthesis and Antiproliferative Activity of Novel Hydrazono Thiazolidene and Thiazole Derivatives Bearing Rhodanine Moiety

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Abstract

Some new fluoro-heterocyclic compounds containing thiazole and pyridine moities have been synthesized and studied for their antiproliferative activity. Thiazole derivatives have been synthesized by the reaction of alpha-halo carbonyl compounds with thiosemicarbazones. Some pyridine derivatives have been synthesized by the reaction of chalcone with cyanothioacetamide and/or malononitrile. Spectroscopic methods have been used for elucidating molecular structures of the products. Cytotoxic activity of several derivatives has been tested against human breast cancer (MCF-7), human colon cancer (HCT-116) and human liver cancer (Hep-G2) by the SRB method. Most of compounds exhibit mild effect on the tested cell lines. One of thiazolidin-4-one derivatives has been characterized by moderate to strong effect on MCF-7 cell line.

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Fig. 1.
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Fig. 2.

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Notes

  1. Method a gave higher yields than method b, lasted for shorter period of time and its procedure was simpler.

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ACKNOWLEDGMENTS

The authors offered a great gratitude to the National Research Center, Egypt for funding this work which is a part of PhD thesis project No 1/6/14. Also the authors are grateful to the Deanship of Scientific Research, king Saud University for funding through Vice Deanship of Scientific Research Chairs.

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Authors and Affiliations

  1. Applied Organic Chemistry Department, National Research Centre, Dokki, 12622, Giza, Egypt

    M. E. A. Elasasy, D. H. Elnaggar, N. A. Abdel Hafez & A. M. Mohamed

  2. Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, 11566, Cairo, Egypt

    M. E. Azab

  3. Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia

    A. E. Amr

  4. Organic Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622, Cairo, Egypt

    A. E. Amr

  5. Cancer Biology Department, Pharmacology Unit, National Cancer Institute, Cairo University, 11796, Cairo, Egypt

    M. M. Omran

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  1. M. E. A. Elasasy
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Correspondence to A. M. Mohamed.

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Elasasy, M.E.A., Elnaggar, D.H., Hafez, N.A.A. et al. Synthesis and Antiproliferative Activity of Novel Hydrazono Thiazolidene and Thiazole Derivatives Bearing Rhodanine Moiety. Russ J Gen Chem 91, 915–925 (2021). https://doi.org/10.1134/S1070363221050236

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