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Design, Synthesis, and Anticancer Activity of Bis-isoxazole Incorporated Benzothiazole Derivatives

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Abstract

A novel series of bis-isoxazole incorporated benzothiazole derivatives has been designed and synthesized. Molecular structures of the compounds have been confirmed by 1H and 13C NMR, and mass spectra. All products have been tested for their in vitro anticancer activity against breast MCF-7 and MDA MB-231, lungs A549, and prostate DU-145 cancer cell lines using the MTT assay and etoposide as a standard drug. Most of the compounds have demonstrated good to moderate activity, and some of those have exhibited more potent activity than etoposide.

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ACKNOWLEDGMENTS

The authors would like to thank the management of the AMRI Hyderabad research Centre for giving an opportunity to carry out this research. The authors are also thankful to Department of Chemistry, Koneru Lakshmaiah Education Foundation for constant encouragement during this research program.

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Authors and Affiliations

  1. Department of Chemistry, Koneru Lakshmaiah Education Foundation, Green Fields, 522502, Vaddeswaram, Guntur, India

    Purna Koteswara Rao Cherukumalli, Bhaskara Rao Tadiboina, Kali Charan Gulipalli & Srinu Bodige

  2. School of Pharmacy, Anurag Group of Institutions, Venkatapur, Ghatkaser, 500088, Medchal, Telangana, India

    Kiran Gangarapu

  3. Department of Chemistry, Kakatiya Institute of Technology and Science, 506015, Warangal, India

    Gattu Sridhar

Authors
  1. Purna Koteswara Rao Cherukumalli
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  2. Bhaskara Rao Tadiboina
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  3. Kali Charan Gulipalli
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  4. Srinu Bodige
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Corresponding author

Correspondence to Bhaskara Rao Tadiboina.

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Cherukumalli, P.K.R., Tadiboina, B.R., Gulipalli, K.C. et al. Design, Synthesis, and Anticancer Activity of Bis-isoxazole Incorporated Benzothiazole Derivatives. Russ J Gen Chem 90, 1981–1989 (2020). https://doi.org/10.1134/S1070363220100229

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  • DOI: https://doi.org/10.1134/S1070363220100229

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