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Indole-3-carbaldehydes Arylhydrazones as Multisite C-Nucleophiles in the Reactions with Quinazoline

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Abstract

C,C-Coupling of indole-3-carbaldehyde arylhydrazones with quinazoline in trifluoroacetic acid has occurred at position 5 or 7′ of the hydrazone molecule and has afforded the σ-adducts. The C,C-coupling has been accompanied by a change in the E-configuration of the C=N bond of the starting hydrazones to the Z-configuration in the formed quinazoline trifluoroacetyl hydrazides.

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Authors and Affiliations

  1. Ural Federal University, 620002, Yekaterinburg, Russia

    Yu. A. Azev, O. S. Koptyaeva, O. S. Eltsov, Yu. A. Yakovleva, A. N. Tsmokalyuk, A. V. Ivoilova, E. A. Seliverstova, T. A. Pospelova & V. A. Bakulev

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  1. Yu. A. Azev
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  2. O. S. Koptyaeva
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  3. O. S. Eltsov
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  4. Yu. A. Yakovleva
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  5. A. N. Tsmokalyuk
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  6. A. V. Ivoilova
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  7. E. A. Seliverstova
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  8. T. A. Pospelova
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  9. V. A. Bakulev
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Correspondence to Yu. A. Azev.

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Azev, Y.A., Koptyaeva, O.S., Eltsov, O.S. et al. Indole-3-carbaldehydes Arylhydrazones as Multisite C-Nucleophiles in the Reactions with Quinazoline. Russ J Gen Chem 90, 1601–1610 (2020). https://doi.org/10.1134/S1070363220090030

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