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Reactions under Pressure: Synthesis of Functionally Substituted Arylhydrazonal Derivatives as Precursors of Novel Pyridazines and Nicotinates

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Abstract

Q-tube assisted multicomponent synthesis of novel arylhydrazonals, pyridazines and nicotinates has been explored. The target molecules have been prepared via one pot reaction of arylhydrazonals with activated methylene nitriles in either ethanolic piperidine, dimethyl acetylene dicarboxylate (DMAD), 1,4-diazobicyclo[2.2.2]octane (DABCO), or Ph3P under pressure. Such conditions make reaction time much shorter and yields higher as compared with those conducted under conventional conditions. The structures of products have been determined by X-ray crystallography and spectroscopic methods.

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Funding

This project was funded by the Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, under grant no. 2-363-36-RG. The authors, therefore, acknowledge with thanks DSR technical and financial support.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences–AL Faisaliah, King Abdulaziz University, 21533, Jeddah, Saudi Arabia

    K. M. Al Zaydi, M. A. Al-Johani, N. F. Alqahtani & S. M. Mousally

  2. Chemistry Department, Faculty of Sciences, University of Jeddah, 21589, Jeddah, Saudi Arabia

    K. M. Al Zaydi, N. F. Alqahtani & S. M. Mousally

  3. College of Science at Yanbu–Taibah University, Almadinah Almunawarah, 41477, Almadinah, Saudi Arabia

    M. A. Al-Johani

  4. Faculty of Pharmacy, Modern University for Technology and Information, 11571, Cairo, Egypt

    N. Hilmy Elnagdi

Authors
  1. K. M. Al Zaydi
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  2. M. A. Al-Johani
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  3. N. F. Alqahtani
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  4. S. M. Mousally
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  5. N. Hilmy Elnagdi
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Correspondence to K. M. Al Zaydi.

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Zaydi, K.M.A., Al-Johani, M.A., Alqahtani, N.F. et al. Reactions under Pressure: Synthesis of Functionally Substituted Arylhydrazonal Derivatives as Precursors of Novel Pyridazines and Nicotinates. Russ J Gen Chem 90, 710–719 (2020). https://doi.org/10.1134/S1070363220040234

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  • DOI: https://doi.org/10.1134/S1070363220040234

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