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Synthesis and Antinociceptive Activity of N-Substituted 4-Aryl-4-oxo-2-[(3-thiophen-2-yl)amino]but-2-enamides

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Abstract

2-{[5-Aryl-2-oxofuran-3(2H)-ylidene]amino}thiophene-3-carboxylic acid derivatives reacted with substituted amines to give new N-substituted 4-aryl-4-oxo-2-[(3-thiophen-2-yl)amino]but-2-enamides. Antinociceptive activity of the synthesized compounds was studied.

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Funding

This work was financially supported by the Russian Foundation for Basic Research (project no. 19-43-590023).

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Authors and Affiliations

  1. Perm State University, 614990, Perm, Russia

    S. A. Shipilovskikh, V. Y. Vaganov, R. R. Makhmudov & A. E. Rubtsov

  2. Ural Federal University, 620002, Yekaterinburg, Russia

    S. A. Shipilovskikh

Authors
  1. S. A. Shipilovskikh
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  2. V. Y. Vaganov
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  3. R. R. Makhmudov
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  4. A. E. Rubtsov
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Correspondence to S. A. Shipilovskikh.

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Shipilovskikh, S.A., Vaganov, V.Y., Makhmudov, R.R. et al. Synthesis and Antinociceptive Activity of N-Substituted 4-Aryl-4-oxo-2-[(3-thiophen-2-yl)amino]but-2-enamides. Russ J Gen Chem 90, 583–589 (2020). https://doi.org/10.1134/S1070363220040040

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