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Synthesis of 3-Phosphorylated Thiazolo[3,2-a]pyrimidine-6-carboxylates

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Abstract

The reaction of diethyl chloroethynylphosphonate with methyl (ethyl) 6-methyl-4-aryl-2-thio-1,2,3,4-tetrahydropyrimidine-5-carboxylate proceeded through the replacement of the chlorine atom and subsequent intramolecular cyclization to yield methyl (ethyl) 3-(diethoxyphosphoryl)-5-aryl-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylates.

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Funding

This work was financially supported by the Russian Foundation for Basic Research (grant no. 18-33-00430) in the framework of the basic part of the governmental task of the Ministry of Science and Higher Education (no. 4.554.2017/8.9) using the equipment of the Engineering Center of the St. Petersburg State Institute of Technology.

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Authors and Affiliations

  1. St. Petersburg State Institute of Technology (Technical University), 190013, St. Petersburg, Russia

    D. M. Egorov, A. A. Babushkina & Yu. L. Piterskaya

  2. Pskov State University, 180000, Pskov, Russia

    V. E. Leonenok & A. P. Chekalov

Authors
  1. D. M. Egorov
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  2. A. A. Babushkina
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  3. V. E. Leonenok
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  4. A. P. Chekalov
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  5. Yu. L. Piterskaya
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Correspondence to D. M. Egorov.

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Egorov, D.M., Babushkina, A.A., Leonenok, V.E. et al. Synthesis of 3-Phosphorylated Thiazolo[3,2-a]pyrimidine-6-carboxylates. Russ J Gen Chem 90, 319–321 (2020). https://doi.org/10.1134/S1070363220020267

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  • DOI: https://doi.org/10.1134/S1070363220020267

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