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Synthesis, characterization and biological evaluation of thiazolopyrimidine derivatives

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Abstract

Different substituted diesters of thiazolopyrimidine were prepared by the treatment of 3,4 dihydropyrimidine2-thione with α-haloesters using ethanol under reflux condition affording 71–85% yield. IR, 1HNMR, 13CNMR and elemental analyses were used for the characterization of these compounds. The crystal and molecular structure of one of the product, 5-phenyl-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine-2,6-dicarboxylic acid diethyl ester (3e) was verified by single crystal X-ray diffraction method. The antimicrobial activity was evaluated against four bacterial strains and one fungal species. Few of the derivatives exhibited antibacterial and antifungal activities.

We have reported the synthesis of some thiazolopyrimidine derivatives by cyclo-condensation of dihydropyrimidine with halo esters. Crystal structure analysis of one of the derivatives has been carried out. Some of the derivatives exhibited antibacterial and antifungal activities.

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Authors and Affiliations

  1. Department of Chemistry, Bangalore University, Bangalore, 560 001, India

    H NAGARAJAIAH & NOOR SHAHINA BEGUM

  2. Department of Chemistry, Karnatak University, Dharwad, 580 003, India

    I M KHAZI

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  1. H NAGARAJAIAH
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Correspondence to NOOR SHAHINA BEGUM.

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NAGARAJAIAH, H., KHAZI, I.M. & BEGUM, N.S. Synthesis, characterization and biological evaluation of thiazolopyrimidine derivatives. J Chem Sci 124, 847–855 (2012). https://doi.org/10.1007/s12039-012-0271-z

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  • DOI: https://doi.org/10.1007/s12039-012-0271-z

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