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Synthesis and Antibacterial Activity of New Acridone Derivatives Containing an Isoxazoline Fragment

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Abstract

A method was developed for the preparation of N-(4-R-4,5-dihydroisoxazol-5-yl)methylacridones by the reaction of aromatic aldehyde oximes with allyl acridones. For the obtained compounds, a high inhibitory activity in relation to test strains of pathogenic microorganisms was revealed, exceeding furacilin.

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Funding

This work was supported by the Ministry of Education and Science of the Russian Federation (project no. 4.9516.2017/BCh).

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Authors and Affiliations

  1. Kursk State University, Kursk, 305000, Russia

    T. N. Kudryavtseva, A. Yu. Lamanov & P. I. Sysoev

  2. Kursk State Medical University, Kursk, 305000, Russia

    L. G. Klimova

Authors
  1. T. N. Kudryavtseva
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  2. A. Yu. Lamanov
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  3. P. I. Sysoev
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  4. L. G. Klimova
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Corresponding author

Correspondence to T. N. Kudryavtseva.

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Conflict of Interest

No conflict of interest was declared by the authors.

Russian Text © The Author(s), 2020, published in Zhurnal Obshchei Khimii, 2020, Vol. 90, No. 1, pp. 57–62.

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Kudryavtseva, T.N., Lamanov, A.Y., Sysoev, P.I. et al. Synthesis and Antibacterial Activity of New Acridone Derivatives Containing an Isoxazoline Fragment. Russ J Gen Chem 90, 45–49 (2020). https://doi.org/10.1134/S1070363220010077

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  • DOI: https://doi.org/10.1134/S1070363220010077

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