Abstract
A mild coupling reaction catalyzed by Ni(acac)2-L4 has been studied. The catalyst acts efficiently in the reaction of biaryl coupling between various electrophiles and common or functionalized aryl Grignard reagents with high functional group tolerance. The study demonstrates that LiCl acts as an essential component in efficient cross-coupling by accelerating reduction of Ni(II) to Ni(0). The new catalytic system for selective couplings of aryl tosylates with aryl chlorides has been developed.
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Funding
The authors gratefully acknowledge the financial support from Hebei Chemical and Pharmaceutical College and the key research and development project Foundation of Hebei Province (17214416). The authors are thankful to Hebei University of Science and Technology for Agilent GC and GCMS, 1H and 13C NMR analysis.
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He, XY., Zhang, ZX., Li, CJ. et al. LiCl-Accelerated Nickel Catalyzed Cross-Coupling of Aryl Tosylates with the Aryl Grignard Reagents. Russ J Gen Chem 89, 2591–2596 (2019). https://doi.org/10.1134/S1070363219120405
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DOI: https://doi.org/10.1134/S1070363219120405