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Catalytic Grignard-Type Addition of Aryl C‐H Bonds to C=O and C=N Bonds

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Chemistry Beyond Chlorine

Abstract

As an alternative to the classical Grignard reaction, transition-metal catalyzed direct addition of aryl C-H bonds to carbonyl groups and their analogues have recently attracted increasing attention due to its atom economy, environmental benefits, abundance of C-H bonds as well as the scientific challenging to achieve mild C-H activations. This chapter briefly summarizes the recent progress in this field, categorized according to different metal catalysts. Applications to synthesize heterocycles and other useful molecules were highlighted as examples. Both the major challenges and the strategies to solve them are discussed in this chapter.

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Acknowledgments

We are indebted to our colleagues, whose name are given in the list of references. We also thank the Canada Research Chair (Tier I) foundation; the CFI, NSERC, and FQRNT; and the CSC (China Scholarship Council) for a postdoctoral scholarship to Feng Wang.

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Authors and Affiliations

  1. Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis (CCVC), McGill University, 801 Sherbrooke Street West, Montreal, QC, H3A 0B8, Canada

    Feng Wang, Wenbo Liu & Chao-Jun Li

Authors
  1. Feng Wang
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  2. Wenbo Liu
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  3. Chao-Jun Li
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Corresponding author

Correspondence to Chao-Jun Li .

Editor information

Editors and Affiliations

  1. Ca' Foscari University of Venice Environmental Sciences, Venice, Italy

    Pietro Tundo

  2. Institute of Elemento-Organic Chemistry, Nankai University Institute of Elemento-Organic Chemistry, Tianjin, China

    Liang-Nian He

  3. Chemistry Department, Lomonosov Moscow State University Chemistry Department, Moscow, Russia

    Ekaterina Lokteva

  4. Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro-RJ, Brazil

    Claudio Mota

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Wang, F., Liu, W., Li, CJ. (2016). Catalytic Grignard-Type Addition of Aryl C‐H Bonds to C=O and C=N Bonds. In: Tundo, P., He, LN., Lokteva, E., Mota, C. (eds) Chemistry Beyond Chlorine. Springer, Cham. https://doi.org/10.1007/978-3-319-30073-3_1

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