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Synthesis of N-Derivatives of Cytisine, Anabasine, and Salsoline Alkaloids with Pharmacophore 3-Aminopyridine-2(1H)-one and 5-Methyl-7-phenyloxazole[5,4-b]pyridine Cycles

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Abstract

The reaction of nucleophilic substitution of 2-chloro-N-(6-methyl-2-oxo-4-phenyl-1,2-dihydropyridin-3-yl)acetamide and 2-(chloromethyl)-5-methyl-7-phenyloxazolo[5,4-b]pyridine with cytisine, anabasine, and salsoline alkaloids has afforded the corresponding derivatives. Structure of the obtained compounds has been confirmed by means of 1H and 13C NMR spectroscopy.

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Funding

This study was financially supported by the Russian Foundation for Basic Research (project no. 18-33-01143).

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Authors and Affiliations

  1. Institute of Chemistry, Tyumen State University, Tyumen, 625003, Russia

    I. V. Palamarchuk & I. V. Kulakov

  2. Omsk O.M. Dostoevskii State University, Omsk, 644077, Russia

    D. N. Ogurtsova

  3. Ualikhanov Kokshetau State University, Kokshetau, 020000, Kazakhstan

    T. M. Seilkhanov

Authors
  1. I. V. Palamarchuk
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  2. D. N. Ogurtsova
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  3. T. M. Seilkhanov
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  4. I. V. Kulakov
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Correspondence to I. V. Palamarchuk.

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Palamarchuk, I.V., Ogurtsova, D.N., Seilkhanov, T.M. et al. Synthesis of N-Derivatives of Cytisine, Anabasine, and Salsoline Alkaloids with Pharmacophore 3-Aminopyridine-2(1H)-one and 5-Methyl-7-phenyloxazole[5,4-b]pyridine Cycles. Russ J Gen Chem 89, 2487–2491 (2019). https://doi.org/10.1134/S1070363219120259

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  • DOI: https://doi.org/10.1134/S1070363219120259

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