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Synthesis, Structure, and Anti-Inflammatory Activity of Functionally Substituted Chalcones and Their Derivatives

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Abstract

Functionally substituted chalcones, pyrazolines, and flavonones have been synthesized. Their structure has been studied by means of 1H and 13C NMR spectroscopy, including COSY and HMQC experiments. Anti-inflammatory activity of the synthesized chalcones, pyrazolines, and flavonones has been evaluated.

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Funding

This study was financially supported by the Ministry of Education and Science of the Russian Federation (project no. 4.6660.2017/8.9) and the Ministry of Education and Science of the Republic of Kazakhstan (project no. AP05133157).

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Authors and Affiliations

  1. Karaganda State Technical University, bul. Mira 56, Karaganda, 100027, Kazakhstan

    O. A. Nurkenov, M. K. Ibraev & M. B. Isabaeva

  2. Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda, Kazakhstan

    O. A. Nurkenov & A. E. Arinova

  3. Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA

    I. A. Schepetkin

  4. N. Kizhner Center, National Research Tomsk Polytechnic University, Tomsk, Russia

    I. A. Schepetkin & A. I. Khlebnikov

  5. I.I. Polzunov Altai State Technical University, Barnaul, Russia

    A. I. Khlebnikov

  6. Sh. Ualikhanov Kokshetau State University, Kokshetau, Kazakhstan

    T. M. Seilkhanov

Authors
  1. O. A. Nurkenov
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  2. M. K. Ibraev
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  3. I. A. Schepetkin
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  4. A. I. Khlebnikov
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  5. T. M. Seilkhanov
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  6. A. E. Arinova
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  7. M. B. Isabaeva
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Corresponding author

Correspondence to M. K. Ibraev.

Additional information

Russian Text © The Author(s), 2019, published in Zhurnal Obshchei Khimii, 2019, Vol. 89, No. 7, pp. 995–1003.

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Nurkenov, O.A., Ibraev, M.K., Schepetkin, I.A. et al. Synthesis, Structure, and Anti-Inflammatory Activity of Functionally Substituted Chalcones and Their Derivatives. Russ J Gen Chem 89, 1360–1367 (2019). https://doi.org/10.1134/S1070363219070028

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  • DOI: https://doi.org/10.1134/S1070363219070028

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