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Synthesis and Antimicrobial Activity of 1-Aryl-4-(arylimino)-6-iminohexahydro-1,3,5-triazine-2-thione Derivatives

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Abstract

A series of 6-imino-1-aryl-4-(arylimino)-1,3,5-triazinane-2-thione derivatives are synthesized by cyclization of 1-aryl-3-cyanoguanidine with aryl isothiocyante in the presence of sodium methoxide under MW irradiation. Structures of the synthesized compounds 3a-j are elucidated from 1H and 13C NMR, MS, and IR, data. The synthesized compounds are evaluated for their antimicrobial activity against B. subtilis, S. aureus, P. aeruginosa, and E. Coli. Some compounds demonstrate promising activity against the tested strains.

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Authors and Affiliations

  1. Division of Chemistry, Department of Science and Humanities, Vignan’s Foundation for Science, Technology and Research University, Guntur, India

    T. Siva Sankara Babu & N. Srinivasu

  2. NACL Industries Limited (R&D Center), Hyderabad, India

    B. Saha & S. Venkat Reddy

Authors
  1. T. Siva Sankara Babu
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  2. N. Srinivasu
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  3. B. Saha
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  4. S. Venkat Reddy
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Correspondence to N. Srinivasu.

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Siva Sankara Babu, T., Srinivasu, N., Saha, B. et al. Synthesis and Antimicrobial Activity of 1-Aryl-4-(arylimino)-6-iminohexahydro-1,3,5-triazine-2-thione Derivatives. Russ J Gen Chem 89, 824–830 (2019). https://doi.org/10.1134/S1070363219040303

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  • DOI: https://doi.org/10.1134/S1070363219040303

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