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Synthesis and Antibacterial Assay of Some New Pyrenyl Pyridine Candidates

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Abstract

Novel polycyclic compounds, 1-pyrene-based pyridone derivatives, are synthesized by treatment of pyrenyl acetohydtazide with several arylidenemalononitriles and acetylacetone. Intramolecular cyclization furnishes the functionalized substituted pyridine-2-ones with high yields. Structures of the products are elucidated from the spectral data. Tests on antibacterial activity of the products reveal their high antibacterial effect.

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Authors and Affiliations

  1. Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    N. M. Khalifa & M. A. Al-Omar

  2. Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Division, National Research Centre, Giza, Egypt

    N. M. Khalifa & M. E. Haiba

  3. Department of Chemistry, Faculty of Science, Menoufia University, Menoufia, Egypt

    M. M. Taha

Authors
  1. N. M. Khalifa
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  2. M. E. Haiba
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  3. M. M. Taha
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  4. M. A. Al-Omar
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Correspondence to N. M. Khalifa.

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Khalifa, N.M., Haiba, M.E., Taha, M.M. et al. Synthesis and Antibacterial Assay of Some New Pyrenyl Pyridine Candidates. Russ J Gen Chem 89, 319–323 (2019). https://doi.org/10.1134/S1070363219020245

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  • DOI: https://doi.org/10.1134/S1070363219020245

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