Skip to main content
SpringerLink
Log in

Synthesis and Molecular Docking Studies of Novel 5-Arylideneaminouracils

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

A series of novel 5-arylideneaminouracils is synthesized from 5-aminouracil and substituted salicylaldehydes, and characterized by spectroscopic methods. DNA interactions of model molecules are explored using molecular docking simulations that reveal that these types of molecules can act as DNA groove binders.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ferreira, L.G., Dos Santos, R. N., Oliva, G., and Andricopulo, A.D., Molecules, 2015, vol. 20, p. 13384. doi https://doi.org/10.3390/molecules200713384

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Sliwoski, G., Kothiwale, S., Meiler, J., and Lowe, E.W., Jr., Pharmacol Rev., 2014, vol. 66, p. 334. doi https://doi.org/10.1124/pr.112.007336

    Article  CAS  PubMed  Google Scholar 

  3. Park, G.Y., Wilson, J.J., Song, Y., and Lippard, S.J., PNAS, 2012, vol. 109, p. 11987. doi https://doi.org/10.1073/pnas.1207670109

    Article  PubMed  PubMed Central  Google Scholar 

  4. Palchaudhuri, R. and Hergenrother, P.J., Curr. Opi. Biotechnol., 2007, vol. 18, p. 497. doi https://doi.org/10.1016/j.copbio.2007.09.006

    Article  CAS  Google Scholar 

  5. Terenzi, A., Lötsch, D., Schoonhoven, S. van Roller, A., Kowol, C.R., Berger, W., Kepplera, B.K., and Barone, G., Dalton Trans., 2016, vol. 45, p. 7758. doi https://doi.org/10.1039/C6DT00648E

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Chaires, J.B., Arch. Biochem. Biophys., 2006, vol. 453, p. 26. doi https://doi.org/10.1016/j.abb.2006.03.027

    Article  CAS  PubMed  Google Scholar 

  7. Suh, D. and Chaires, J.B., Bioorg. Med. Chem., 1995, vol. 3, p. 723. doi https://doi.org/10.1016/0968-0896(95)00053-J

    Article  CAS  PubMed  Google Scholar 

  8. Cai, X., Gray, P.J., Jr., and Von Hoff, D.D., Cancer Treat. Rev., 2009, vol. 35, p. 437. doi https://doi.org/10.1016/j.ctrv.2009.02.004

    Article  CAS  Google Scholar 

  9. Murtaza, S., Abbas, A., Iftikhar, K., Shamim, S., Akhtar, M.S., Razzaq, Z., Naseem, K., and Elgorban, A.M., Med. Chem. Res., 2016, vol. 25, p. 2860. doi https://doi.org/10.1007/s0004

    Article  CAS  Google Scholar 

  10. Kirubavathy, S.J., Velmuruga, R., Karvembu, R., Bhuvanesh, N.S.P., Enoch, I.V.M.V., Selvakumar, P.M., Premnath, D. and Chitra, S., J. Mol. Struct., 2017, vol. 1127, p. 345. doi https://doi.org/10.1016/j.molstruc.2016.07.082

    Article  CAS  Google Scholar 

  11. Hemamalini, A., Singam, E.R.A., Mudedla, S.K., Subramanian, V., and Das, T.M., New J. Chem., 2015, vol. 39, p. 4575. doi https://doi.org/10.1039/C4NJ02221A

    Article  CAS  Google Scholar 

  12. Haq, I., Arch. Biochem. Biophys., 2002, vol. 403, p. 1. doi https://doi.org/10.1016/S0003-9861(02)00202-3

    Article  CAS  PubMed  Google Scholar 

  13. Haq, I., Ladbery, J.H., Chowdhry, B.Z., Jenkins, T.C., and Chaires, J.B., J. Mol. Biol., 1997, vol. 271, p. 244. doi https://doi.org/10.1006/jmbi.1997.1170

    Article  CAS  PubMed  Google Scholar 

  14. Frisch, M.J., Trucks, G.W., Schlegel, H.B., Scuseria, G.E., Robb, M.A., Cheeseman, J.R., Montgomery, Jr. J.A., Vreven, T., Kudin, K.N., Burant, J.C., Millam, J.M., Iyengar, S.S., Tomasi, J., Barone, V., Mennucci, B., Cossi, M., Scalmani, G., Rega, N., Petersson, G.A., Nakatsuji, H., Hada, M., Ehara, M., Toyota, K., Fukuda, R., Hasegawa, J., Ishida, M., Nakajima, T., Honda, Y., Kitao, O., Nakai, H., Klene, M., Li, X., Knox, J.E., Hratchian, H.P., Cross, J.B., Bakken, V., Adamo, C., Jaramillo, J., Gomperts, R., Stratmann, R. E., Yazyev, O., Austin, A.J., Cammi, R., Pomelli, C., Ochterski, J.W., Ayala, P.Y., Morokuma, K., Voth, G.A., Salvador, P., Dannenberg, J.J., Zakrzewski, V.G., Dapprich, S., Daniels, A.D., Strain, M.C., Farkas, O., Malick, O.D.K., Rabuck, A.D., Raghavachari, K., Foresman, J.B., Ortiz, J.V., Cui, Q., Baboul, A.G., Clifford, S., Cioslowski, J., Stefanov, B.B., Liu, G., Liashenko, A., Piskorz, P., Komaromi, I., Martin, R.L., Fox, D.J., Keith, T., Al-Laham, M.A., Peng, C.Y., Nanayakkara, A., Challacombe, M., Gill, P.M.W., Johnson, B., Chen, W., Wong, M.W.C., Gonzalez, C., and Pople, J.A., Gaussian 03, Revision C.02. Gaussian, Inc.,Wallingford CT, 2004.

    Google Scholar 

  15. Becke, A.D., J. Chem. Phys., 1993, vol. 98, p. 5648. doi https://doi.org/10.1063/1.464913

    Article  CAS  Google Scholar 

  16. Trott, O. and Olson, A. J., J. Comput. Chem., 2010, vol. 31, p. 455. doi https://doi.org/10.1002/jcc.21334

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Bursa Technical University, Bursa, 16190, Turkey

    G. Koz

Authors
  1. G. Koz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. Koz.

Additional information

Supporting materials are available from author.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Koz, G. Synthesis and Molecular Docking Studies of Novel 5-Arylideneaminouracils. Russ J Gen Chem 89, 122–127 (2019). https://doi.org/10.1134/S1070363219010225

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070363219010225

Keywords

Search

Navigation