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N-Propargyl-α-aminophosphonates in 1,3-Dipolar Cycloaddition with Azide-Containing Pharmacophores

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Abstract

Some transformations of N-propargyl-α-aminophosphonates synthesized by the Kubachnik–Fields reaction were studied in copper-catalyzed 1,3-dipolar cycloaddition with azide-containing pharmacophores (phenothiazine, tetrahydrocarbazole, carbazole, and 3,5-dimethyl-1-aminoadamantane) leading to the formation of the corresponding 1,4-substituted 1,2,3-triazoles and allowing the introduction of a diethoxyphosphoryl fragment into the molecules of potential neuroprotectors.

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Authors and Affiliations

  1. Institute of Physiologically Active Substances of the Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, 142432, Russia

    V. B. Sokolov & A. Yu. Aksinenko

Authors
  1. V. B. Sokolov
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  2. A. Yu. Aksinenko
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Correspondence to A. Yu. Aksinenko.

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Dedicated to the 110th anniversary of M.I. Kabachnik’s birth

Original Russian Text © V.B. Sokolov, A.Yu. Aksinenko, 2018, published in Zhurnal Obshchei Khimii, 2018, Vol. 88, No. 9, pp. 1554–1558.

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Sokolov, V.B., Aksinenko, A.Y. N-Propargyl-α-aminophosphonates in 1,3-Dipolar Cycloaddition with Azide-Containing Pharmacophores. Russ J Gen Chem 88, 1922–1926 (2018). https://doi.org/10.1134/S107036321809027X

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  • DOI: https://doi.org/10.1134/S107036321809027X

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