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Molecular construction of multitarget neuroprotectors 1. Synthesis and biological activity of conjugates of substituted indoles and bis(dimethylamino)phenothiazine

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Abstract

Synthetic strategy to access new multitarget neuroprotectors by conjugation of pharma-cophoric indole and bis(dimethylamino)phenothiazine moieties via 1-oxopropylene spacer was developed. The transformation was achieved by the cesium fluoride-catalyzed reaction of cycloalkaneindoles with 1-propenone. Effect of the synthesized compounds on neuronal NMDA receptors was evaluated by radioligand binding assay.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow Region, Russian Federation

    S. O. Bachurin, V. B. Sokolov, A. Yu. Aksinenko, T. A. Epishina, T. V. Goreva, A. V. Gabrel´yan & V. V. Grigor´ev

Authors
  1. S. O. Bachurin
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  2. V. B. Sokolov
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  3. A. Yu. Aksinenko
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  4. T. A. Epishina
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  5. T. V. Goreva
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  6. A. V. Gabrel´yan
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  7. V. V. Grigor´ev
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Corresponding author

Correspondence to A. Yu. Aksinenko.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1354–1361, June, 2015.

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Bachurin, S.O., Sokolov, V.B., Aksinenko, A.Y. et al. Molecular construction of multitarget neuroprotectors 1. Synthesis and biological activity of conjugates of substituted indoles and bis(dimethylamino)phenothiazine. Russ Chem Bull 64, 1354–1361 (2015). https://doi.org/10.1007/s11172-015-1017-0

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  • DOI: https://doi.org/10.1007/s11172-015-1017-0

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