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One-Pot Four Component Synthesis of 3-Amino-1-(1H-indol-2-yl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine Derivatives Mediated by [DBUH][OAc]

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Abstract

One-pot, four component, green, and efficient synthesis of 3-amino-1-(5-nitro-1H-indol-2-yl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine derivatives by reaction of phthalic anhydride with hydrazine hydrate, 5-nitro-1H-indole-3-carboxaldehyde–indole-3-carboxaldehydes and malononitrile–ethyl cyanoacetate in the presence of [DBUH][OAc] at 60–65°C is developed. The method is characterized by short reaction time, high yields, and purity of products formed.

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Authors and Affiliations

  1. Department of Organic Chemistry, Foods, Drug and Water, College of Science and Technology, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India

    G. Jeevan Raghavendra & V. Siddaiah

Authors
  1. G. Jeevan Raghavendra
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  2. V. Siddaiah
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Correspondence to G. Jeevan Raghavendra.

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Jeevan Raghavendra, G., Siddaiah, V. One-Pot Four Component Synthesis of 3-Amino-1-(1H-indol-2-yl)-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine Derivatives Mediated by [DBUH][OAc]. Russ J Gen Chem 88, 1892–1898 (2018). https://doi.org/10.1134/S1070363218090219

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