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Synthesis, Characterization, and Antimicrobial Assessment of Some Computationally Bioactive 1,2-Oxazole Derivatives

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Abstract

1,2-Oxazole derivatives 1–6 were designed and evaluated computationally to calculate the physicochemical properties and the bioactivity score by Mol-inspiration, and were determined to possess very good activity score. 1,2-Oxazoles were then synthesized, characterized by FT-IR, 1H NMR and mass spectroscopy, and tested for antibacterial activity against the pathogens (Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Proteus mirabilis). The antibacterial therapeutic effect strongly supported the prior computational results. Four synthesized compounds 2, 4–6 demonstrated antibacterial potential higher than the standard drug Ciprofloxacin.

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Authors and Affiliations

  1. Department of Basic Sciences, College of Medicine Al-Dawadmi, Shaqra University, Shaqra, Saudi Arabia

    M. Arshad

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  1. M. Arshad
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Arshad, M. Synthesis, Characterization, and Antimicrobial Assessment of Some Computationally Bioactive 1,2-Oxazole Derivatives. Russ J Gen Chem 88, 1886–1891 (2018). https://doi.org/10.1134/S1070363218090207

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  • DOI: https://doi.org/10.1134/S1070363218090207

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