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The First 1-Hydroxypropylidenebisphosphonic Acid with 1,8-Naphthyridinone Substituent: Synthesis and Structure

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Abstract

1-Hydroxy-3-(5,7-dimethyl-2-oxo-1,2-dihydro-1,8-naphthyridin-1-yl)propylidenebisphosphonic acid has been synthesized. The structure of the acid and its precursors synthesized for the first time, 3-(5,7-dimethyl-2-oxo-1,2-dihydro-1,8-naphthyridin-1-yl)propionic acid and the corresponding methyl ester, in the solid state and in the DMSO solution has been elucidated by means of vibrational (IR and Raman) and multinuclear (1H, 13C, and 31P) NMR spectroscopy.

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Authors and Affiliations

  1. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Moscow, 119991, Russia

    G. V. Bodrin, M. P. Pasechnik, A. G. Matveeva, R. R. Aysin, S. V. Matveev, E. I. Goryunov, T. V. Strelkova & V. K. Brel

Authors
  1. G. V. Bodrin
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  2. M. P. Pasechnik
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  3. A. G. Matveeva
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  4. R. R. Aysin
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  5. S. V. Matveev
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  6. E. I. Goryunov
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  7. T. V. Strelkova
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  8. V. K. Brel
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Correspondence to A. G. Matveeva.

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Dedicated to the 110th anniversary of M.I. Kabachnik’s birth

Original Russian Text © G.V. Bodrin, M.P. Pasechnik, A.G. Matveeva, R.R. Aysin, S.V. Matveev, E.I. Goryunov, T.V. Strelkova, V.K. Brel, 2018, published in Zhurnal Obshchei Khimii, 2018, Vol. 88, No. 9, pp. 1445–1452.

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Bodrin, G.V., Pasechnik, M.P., Matveeva, A.G. et al. The First 1-Hydroxypropylidenebisphosphonic Acid with 1,8-Naphthyridinone Substituent: Synthesis and Structure. Russ J Gen Chem 88, 1792–1799 (2018). https://doi.org/10.1134/S1070363218090050

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