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Microwave Assisted, Solvent-Free, “Green” Synthesis of Novel Indole Analogs as Potent Antitubercular and Antimicrobial Agents and Their Molecular Docking Studies

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Abstract

A rapid, efficient and environmentally benign synthesis of novel indole analogs bearing thiazolidinone attached to substituted thiazolyl coumarin scaffolds are synthesized. Conventional and microwave-assisted (MW) approaches are studied. Structures of the products are confirmed by FT-IR, NMR (1H and 13C) and Mass spectra. The in vitro antitubercular and antimicrobial activities are evaluated. Several screened compounds demonstrate promising anti-TB and antimicrobial properties. The structure activity relationship (SAR) study reveal that the compounds containing halogens are most potent. Docking of the potent compounds inside the active site of a target enzyme mycobacterial enoyl reductase (InhA)(PDB code 4TZK) is performed.

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Authors and Affiliations

  1. Central Research Laboratory, Department of Chemistry, Gulbarga University, Kalaburagi, Karnataka, 585106, India

    A. S. Rathod, S. S. Godipurge & J. S. Biradar

Authors
  1. A. S. Rathod
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  2. S. S. Godipurge
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  3. J. S. Biradar
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Correspondence to A. S. Rathod.

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Rathod, A.S., Godipurge, S.S. & Biradar, J.S. Microwave Assisted, Solvent-Free, “Green” Synthesis of Novel Indole Analogs as Potent Antitubercular and Antimicrobial Agents and Their Molecular Docking Studies. Russ J Gen Chem 88, 1238–1246 (2018). https://doi.org/10.1134/S1070363218060324

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  • DOI: https://doi.org/10.1134/S1070363218060324

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