Abstract
One-pot, three components, conventional and microwave-assisted synthesis of bisindolyl analogs is described. Michael addition of preformed 2,5-disubstituted indole-3-carboxaldehydes and 3-methyl-1H-pyrazol-5(4H)-one with 2,5-disubstituted indoles under solvent and catalyst-free conditions afforded the hitherto unreported 2,5-disubstituted bisindolyl analogs bearing a pyrazolone moiety in excellent yields. All the synthesized compounds were characterized using IR, 1H NMR, mass spectral, and analytical data. The analogs were screened for in vitro cytotoxic and DNA cleavage studies. Among the screened compounds 4c, 4f, and 4h–4j have emerged as most potent cytotoxic and 4c and 4f–4h as active DNA cleavage analogs.
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Acknowledgments
Sasidhar B.S. thanks the Council of Scientific and Industrial Research, New Delhi (India), for the award of a Senior Research Fellowship (Ref. No. 9/450(0032)2K10-EMR-I). We also thank the Director of IISc (Bangalore) and IIT (madras) for spectroscopic analysis and BIOGENICS, Hubli, for their assistance in carrying out biological activities.
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Sasidhar, B.S., Biradar, J.S. Synthesis of some bisindolyl analogs for in vitro cytotoxic and DNA cleavage studies. Med Chem Res 22, 3518–3526 (2013). https://doi.org/10.1007/s00044-012-0370-x
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DOI: https://doi.org/10.1007/s00044-012-0370-x