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Three-Component One-Pot Synthesis of New 2,5,6,7- and 2,5,8,10-Substituted Pyrimido[4,5-b]quinoline-4,6-diones and -2,4,6-Triones

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Abstract

A series of new pyrimido[4,5-b]quinoline derivatives was synthesized by three-component cyclocondensation of 2-R1-6-aminopyrimidine-4-ones, 5,5-dimethylcyclohexane-1,3-dione (dimedone), and aromatic or heterocyclic aldehydes in a water medium in the presence of triethylbenzylammonium chloride. The replacement of the primary amino group in the position 6 of the key 6-aminopyrimidin-4-one with the secondary amino group led to the formation of 10-substituted analogs of pyrimido[4,5-b]quinolines which are of interest for biological screening.

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Authors and Affiliations

  1. Mnjhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, pr. Azatutyan 26, Yerevan, 0014, Armenia

    T. R. Hovsepyan, G. S. Karakhanyan & S. G. Israelyan

  2. Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia

    G. A. Panosyan

Authors
  1. T. R. Hovsepyan
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  2. G. S. Karakhanyan
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  3. S. G. Israelyan
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  4. G. A. Panosyan
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Correspondence to T. R. Hovsepyan.

Additional information

Original Russian Text © T.R. Hovsepyan, G.S. Karakhanyan, S.G. Israelyan, G.A. Panosyan, 2018, published in Zhurnal Obshchei Khimii, 2018, Vol. 88, No. 6, pp. 933–938.

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Hovsepyan, T.R., Karakhanyan, G.S., Israelyan, S.G. et al. Three-Component One-Pot Synthesis of New 2,5,6,7- and 2,5,8,10-Substituted Pyrimido[4,5-b]quinoline-4,6-diones and -2,4,6-Triones. Russ J Gen Chem 88, 1114–1119 (2018). https://doi.org/10.1134/S1070363218060117

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  • DOI: https://doi.org/10.1134/S1070363218060117

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