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Synthesis and Biological Activity of Compounds Obtained by Reacting Methyl Aroylpyruvates with Sulfadimidine

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Abstract

The reaction of methyl aroylpyruvates and 2-(4-aminobenzenesulfamido)-4,6-dimethylpyrimidine in glacial acetic acid in the presence of anhydrous sodium acetate afforded (2Z)-4-aryl-2-hydroxy-N-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-4-oxobut-2-enamides. Reaction of the above reagents in a mixture of acetic acid and ethanol (1: 1) in the absence of anhydrous sodium acetate gave methyl (2Z)-4-aryl-2-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylamino}-4-oxobut-2-enoates. Analgesic and anti-inflammatory activities of the synthesized compounds was studied.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, ul. Polevaya 2, Perm, 614990, Russia

    V. L. Gein, O. V. Bobrovskaya & V. D. Belonogova

  2. Perm State National Research University, Perm, Russia

    M. V. Dmitriev & R. R. Makhmudov

Authors
  1. V. L. Gein
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  2. O. V. Bobrovskaya
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  3. M. V. Dmitriev
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  4. R. R. Makhmudov
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  5. V. D. Belonogova
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Correspondence to V. L. Gein.

Additional information

Original Russian Text © V.L. Gein, O.V. Bobrovskaya, M.V. Dmitriev, R.R. Makhmudov, V.D. Belonogova, 2018, published in Zhurnal Obshchei Khimii, 2018, Vol. 88, No. 6, pp. 914–921.

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Gein, V.L., Bobrovskaya, O.V., Dmitriev, M.V. et al. Synthesis and Biological Activity of Compounds Obtained by Reacting Methyl Aroylpyruvates with Sulfadimidine. Russ J Gen Chem 88, 1095–1102 (2018). https://doi.org/10.1134/S1070363218060087

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  • DOI: https://doi.org/10.1134/S1070363218060087

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