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Acid-Base Equilibrium of 5-Methoxy-6-methyluracil in Solutions: Evaluation of Content of Anionic Forms in Aqueous Alkaline Solution

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Abstract

Dissociation constants of 5-methoxy-6-methyluracil, 5-methoxy-1,6-dimethyluracil and 5-methoxy-3,6-dimethyluracil in water are determined. Basing on the obtained рKа1 values, the content of anions in aqueous alkaline solution of 5-methoxy-6-methyluracil was calculated. The results were confirmed by the use of model compounds: 5-methoxy-1,6-dimethyluracil and 5-methoxy-3,6-dimethyluracil using the NMR spectroscopy.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054, Russia

    S. F. Petrova, T. R. Nugumanov, L. V. Spirikhin, Yu. I. Murinov & S. P. Ivanov

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  1. S. F. Petrova
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  2. T. R. Nugumanov
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  3. L. V. Spirikhin
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  4. Yu. I. Murinov
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  5. S. P. Ivanov
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Correspondence to S. P. Ivanov.

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Original Russian Text © S.F. Petrova, Т.R. Nugumanov, L.V. Spirikhin, Yu.I. Murinov, S.P. Ivanov, 2018, published in Zhurnal Obshchei Khimii, 2018, Vol. 88, No. 6, pp. 895–899.

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Petrova, S.F., Nugumanov, T.R., Spirikhin, L.V. et al. Acid-Base Equilibrium of 5-Methoxy-6-methyluracil in Solutions: Evaluation of Content of Anionic Forms in Aqueous Alkaline Solution. Russ J Gen Chem 88, 1076–1080 (2018). https://doi.org/10.1134/S107036321806004X

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  • DOI: https://doi.org/10.1134/S107036321806004X

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