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Russian Journal of General Chemistry

, Volume 88, Issue 4, pp 804–811 | Cite as

Synthesis, Molecular Docking, Analgesic, and Anti-Inflammatory Activities of New 1,2,4-Oxadiazolo-Sulfonamides

  • M. Vijaya Bhargavi
  • P. Shashikala
  • M. Sumakanth
  • C. Krishna
Article
  • 24 Downloads

Abstract

In the present study novel 1,2,4-oxadiazolo sulfonamides 3a–3o are synthesized by an efficient method based on the reaction of 1,2,4-oxadiazole amines with aryl sulfonyl chlorides. Structures of the synthesized compounds are confirmed by IR, NMR and Mass spectra. Molecular interactions of the obtained compounds are studied by Discovery Studio v3.5, molecular docking with COX-2 enzyme. The compounds with high LibDock score are screened for their in vivo analgesic and anti inflammatory activities. The compound 3l demonstrates the highest activity.

Keywords

1,2,4-oxadiazole sulfonamide molecular docking analgesic anti inflammatory activity 

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Notes

Acknowledgments

Authors express their thanks to Head-Department of University College of Technology, Osmania University and management of RBVRR Women’s College of Pharmacy for their constant support and providing necessary facilities.

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • M. Vijaya Bhargavi
    • 1
    • 2
  • P. Shashikala
    • 1
  • M. Sumakanth
    • 2
  • C. Krishna
    • 3
  1. 1.Department of Pharmacy, Faculty of TechnologyOsmania UniversityHyderabadIndia
  2. 2.RBVRR Women’s College of PharmacyOsmania UniversityHyderabadIndia
  3. 3.Department of ChemistryOsmania UniversityHyderabadIndia

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