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New promising porphyrazine-based agents for optical theranostics of cancer

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Abstract

New porphyrazine bases containing peripheral benzyloxyphenyl groups have been synthesized by the template method. The procedure includes condensation of aromatic aldehydes with malononitrile, transformation of arylmethylidenemalononitriles to arylethenetricarbonitriles, template assembly of porphyrazine macrocycle on bis(indenyl)ytterbium(II) complex, and removal of the central metal ion. Luminescence properties of the synthesized porphyrazines and their dependence on the viscosity of the medium were studied, and the light and dark toxicities of the porphyrazines have been estimated. The obtained results suggest the possibility of using these porphyrazines as optical theranostic agents of new generation.

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Authors and Affiliations

  1. Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences, ul. Tropinina 49, Nizhny Novgorod, 603137, Russia

    S. A. Lermontova, I. S. Grigor’ev, E. Yu. Ladilina & L. G. Klapshina

  2. Lobachevsky State University of Nizhny Novgorod, pr. Gagarina 23, Nizhny Novgorod, 603950, Russia

    S. A. Lermontova, N. N. Peskova, I. V. Balalaeva & L. G. Klapshina

  3. St. Petersburg State University, Universitetskaya nab. 7–9, St. Petersburg, 199034, Russia

    I. S. Grigor’ev & V. P. Boyarskii

Authors
  1. S. A. Lermontova
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  2. I. S. Grigor’ev
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  3. N. N. Peskova
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  4. E. Yu. Ladilina
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  5. I. V. Balalaeva
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  6. L. G. Klapshina
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  7. V. P. Boyarskii
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Corresponding author

Correspondence to V. P. Boyarskii.

Additional information

Original Russian Text © S.A. Lermontova, I.S. Grigor’ev, N.N. Peskova, E.Yu. Ladilina, I.V. Balalaeva, L.G. Klapshina, V.P. Boyarskii, 2017, published in Zhurnal Obshchei Khimii, 2017, Vol. 87, No. 3, pp. 474–480.

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Lermontova, S.A., Grigor’ev, I.S., Peskova, N.N. et al. New promising porphyrazine-based agents for optical theranostics of cancer. Russ J Gen Chem 87, 479–484 (2017). https://doi.org/10.1134/S1070363217030173

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  • DOI: https://doi.org/10.1134/S1070363217030173

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