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Synthesis of novel 2-phenoxybenzo[g][1,2,4]triazolo[1,5-a]quinazoline and its derivatives starting with diphenyl-N-cyanoimidocarbonate

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Abstract

Cyclocondensation reaction of 3-hydrazinyl-2-naphthoic acid with diphenyl-N-cyanoimidocarbonate furnished the target 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazolin-5(4H)-one (1) in high yield. Alkylation, thionation and chlorination of the lactam group in the compound 1 produced a variety of derivatives 2–17. Their structures were characterized by NMR and HREI-MS analyses.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. box 2457, Riyadh, 11451, Saudi Arabia

    R. A. Al-Salahi & M. S. Marzouk

  2. Chemistry of Natural Products Group, Center of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo, 12622, Egypt

    M. S. Marzouk

Authors
  1. R. A. Al-Salahi
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  2. M. S. Marzouk
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Corresponding authors

Correspondence to R. A. Al-Salahi or M. S. Marzouk.

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The text was submitted by the authors in English.

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Al-Salahi, R.A., Marzouk, M.S. Synthesis of novel 2-phenoxybenzo[g][1,2,4]triazolo[1,5-a]quinazoline and its derivatives starting with diphenyl-N-cyanoimidocarbonate. Russ J Gen Chem 86, 1741–1746 (2016). https://doi.org/10.1134/S1070363216070331

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  • DOI: https://doi.org/10.1134/S1070363216070331

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