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Substituted 2-(2-Arylethenyl)quinazolines. Synthesis and Structure

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Abstract

The reaction of 2-methyl-4H-3,1-benzoxazin-4-one and its 6-iodo derivatives with a number of amines in polyphosphoric acid afforded 3- and 3,6-substituted 2-methylquinazolin-4(3H)-ones. The latter reacted with aromatic and heterocyclic aldehydes under solvent-free conditions to give 2-[(E)-2-arylethenyl]-quinazolin-4(3H)-ones. The structure of the synthesized compounds was confirmed by two-dimensional 1H–1H NOESY data and X-ray analysis.

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References

  1. Ajani, O.O., Audu, O.Y., Aderohunmu, D.V., Owolabi, E.O., and Olomieja, A.O., Am. J. Drug Discovery Dev., 2017, vol. 7, p. 1. doi 10.3923/ajdd.2017.1.24

    Article  CAS  Google Scholar 

  2. Anschütz, R., Schmidt, O., and Greiffenberg, A., Ber., 1902, vol. 35, p. 3482.

    Google Scholar 

  3. Agbo, E.N., Makhafola, T.J., Choong, Y.S., Mphahlele, M.J., and Ramasami, P.R., Molecules, 2016, vol. 21, p. 28. doi 10.3390/molecules21010028

    Article  Google Scholar 

  4. Harutyunyan, A.A., Ghukasyan, G.T., and Danagulyan, G.G., Org. Med. Chem. Int. J., 2018, vol. 7, p. 1. doi 10.19080/OMCIJ.2018.07.555718

    Google Scholar 

  5. Arutyunyan, A.A., Gukasyan, G.T., Panosyan, G.A., and Danagulyan, G.G., Khim. Zh. Arm., 2018, vol. 71, p. 249.

    Google Scholar 

  6. Sheldrick, G.M., Acta Crystallogr., Sect. C, 2015, vol. 71, p. 3.

    Article  Google Scholar 

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Funding

This study was performed at the Russian Armenian University under financial support by the Ministry of Science and Higher Education of the Russian Federation.

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Authors and Affiliations

  1. Russian Armenian (Slavic) University, Yerevan, Armenia

    A. A. Harutyunyan, G. T. Gukasyan & G. G. Danagulyan

  2. Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, Yerevan, Armenia

    A. A. Harutyunyan, H. A. Panosyan, R. A. Tamazyan, A. G. Ayvazyan & G. G. Danagulyan

Authors
  1. A. A. Harutyunyan
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  2. G. T. Gukasyan
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  3. H. A. Panosyan
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  4. R. A. Tamazyan
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  5. A. G. Ayvazyan
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  6. G. G. Danagulyan
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Corresponding author

Correspondence to A. A. Harutyunyan.

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The authors declare the absence of conflict of interests.

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Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 9, pp. 1453–1460.

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Harutyunyan, A.A., Gukasyan, G.T., Panosyan, H.A. et al. Substituted 2-(2-Arylethenyl)quinazolines. Synthesis and Structure. Russ J Org Chem 55, 1363–1369 (2019). https://doi.org/10.1134/S107042801909015X

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  • DOI: https://doi.org/10.1134/S107042801909015X

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