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Synthesis of 6-methyl-2-[2-phenyl-2-(arylhydrazono)ethyl]-3Н-pyrimidine-4-ones and their oxidation by hydrogen peroxide and selenium dioxide

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Abstract

The reaction of 6-methyl-2-(2-oxo-2-phenylethylidene)-2,3-dihydropyrimidine-4(1H)-one with arylhydrazines leads in high yields to the corresponding hydrazones, in which the ethylidene fragment of the starting compound is transformed to the ethylene fragment. By oxidation of the hydrazones with hydrogen peroxide or selenium dioxide the corresponding 6-methyl-2-[2-phenyl-2-(arylhydrazono)acetyl]-3H-pyrimidine-4-ones were synthesized.

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Authors and Affiliations

  1. Bogatskii Physicochemical Institute, National Academy of Sciences of Ukraine, Lyustdorfskaya doroga 86, Odessa, 65080, Ukraine

    A. A. Yavolovskii, S. M. Pluzhnik-Gladyr, Yu. E. Ivanov, D. E. Stepanov, L. V. Grishchuk & G. L. Kamalov

Authors
  1. A. A. Yavolovskii
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  2. S. M. Pluzhnik-Gladyr
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  3. Yu. E. Ivanov
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  4. D. E. Stepanov
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  5. L. V. Grishchuk
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  6. G. L. Kamalov
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Corresponding author

Correspondence to S. M. Pluzhnik-Gladyr.

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Original Russian Text © A.A. Yavolovskii, S.M. Pluzhnik-Gladyr, Yu.E. Ivanov, D.E. Stepanov, L.V. Grishchuk, G.L. Kamalov, 2016, published in Zhurnal Obshchei Khimii, 2016, Vol. 86, No. 7, pp. 1126–1129.

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Yavolovskii, A.A., Pluzhnik-Gladyr, S.M., Ivanov, Y.E. et al. Synthesis of 6-methyl-2-[2-phenyl-2-(arylhydrazono)ethyl]-3Н-pyrimidine-4-ones and their oxidation by hydrogen peroxide and selenium dioxide. Russ J Gen Chem 86, 1604–1607 (2016). https://doi.org/10.1134/S1070363216070112

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  • DOI: https://doi.org/10.1134/S1070363216070112

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