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Synthesis of 2,5-di(hydroxyalkyl)-1,3-thiazoles

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Abstract

A general approach towards synthesis of 2(5)-hydroxyalkyl-substituted 1,3-thiazole derivatives has been proposed. The method includes lithiation of 1,3-thiazole ring followed by reacting the formed thiazole lithium derivatives with electrophiles.

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, ul. Murmanskaya 1, Kiev, 02660, Ukraine

    V. O. Sinenko, S. R. Slivchuk & V. S. Brovarets

  2. Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Science, Kiev, Ukraine

    Ya. G. Bal’on

Authors
  1. V. O. Sinenko
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  2. S. R. Slivchuk
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  3. Ya. G. Bal’on
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  4. V. S. Brovarets
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Corresponding author

Correspondence to V. S. Brovarets.

Additional information

Original Russian Text © V.O. Sinenko, S.R. Slivchuk, Ya.G. Bal’on, V.S. Brovarets, 2015, published in Zhurnal Obshchei Khimii, 2015, Vol. 85, No. 8, pp. 1298–1304.

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Sinenko, V.O., Slivchuk, S.R., Bal’on, Y.G. et al. Synthesis of 2,5-di(hydroxyalkyl)-1,3-thiazoles. Russ J Gen Chem 85, 1855–1861 (2015). https://doi.org/10.1134/S1070363215080113

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  • DOI: https://doi.org/10.1134/S1070363215080113

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