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Synthesis of 2-aryl-2-trifluoromethyl-1,3-thiazolidin-4-ones and 2-aryl-2-trifluoromethyltetrahydro-4H-1,3-thiazin-4-ones and their oxidation with hydrogen peroxide

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Abstract

Reactions of aryl trifluoromethyl ketone imines with 2-sulfanylacetic and 3-sulfanylpropanoic acids afforded 2-aryl-2-trifluoromethyl-1,3-thiazolidin-4-ones and 2-aryl-2-trifluoromethyltetrahydro-4H-1,3-thiazin-4-ones, respectively. Their subsequent oxidation with hydrogen peroxide gave the corresponding 2-aryl-2-trifluoromethyl-1,3-thiazolidin-4-one 1-oxides and 2-aryl-2-trifluoromethyltetrahydro-4H-1,3-thiazin-4-one 1-oxides and 1,1-dioxides.

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Authors and Affiliations

  1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, ul. Murmanskaya 5, Kiev, 02660, Ukraine

    N. V. Mel’nichenko, A. V. Bentya, E. B. Rusanov & M. V. Vovk

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  1. N. V. Mel’nichenko
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  2. A. V. Bentya
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  3. E. B. Rusanov
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  4. M. V. Vovk
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Correspondence to M. V. Vovk.

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Original Russian Text © N.V. Mel’nichenko, A.V. Bentya, E.B. Rusanov, M.V. Vovk, 2015, published in Zhurnal Obshchei Khimii, 2015, Vol. 85, No. 6, pp. 973–979.

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Mel’nichenko, N.V., Bentya, A.V., Rusanov, E.B. et al. Synthesis of 2-aryl-2-trifluoromethyl-1,3-thiazolidin-4-ones and 2-aryl-2-trifluoromethyltetrahydro-4H-1,3-thiazin-4-ones and their oxidation with hydrogen peroxide. Russ J Gen Chem 85, 1440–1446 (2015). https://doi.org/10.1134/S1070363215060134

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  • DOI: https://doi.org/10.1134/S1070363215060134

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