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Synthesis and antibacterial activity of 4-aryl-2-hydroxy-4-oxo-2-butenoic (aroylpyruvic) acids N-(4-guanidylsulfonylphenyl)amides

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Abstract

Reaction of methyl aroylpyruvates with 4-aminobenzolsulfonylguanidine in acetic acid in the presence of anhydrous sodium acetate afforded N-(4-guanidylsulfonylphenyl)amides of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids. Antibacterial activity of the synthesized compounds was studied.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, ul. Polevaya 2, Perm, 614990, Russia

    V. L. Gein, O. V. Bobrovskaya, I. V. Kovtonogova & V. V. Novikova

Authors
  1. V. L. Gein
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  2. O. V. Bobrovskaya
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  3. I. V. Kovtonogova
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  4. V. V. Novikova
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Correspondence to V. L. Gein.

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Original Russian Text © V.L. Gein, O.V. Bobrovskaya, I.V. Kovtonogova, V.V. Novikova, 2015, published in Zhurnal Obshchei Khimii, 2015, Vol. 85, No. 4, pp. 588–591.

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Gein, V.L., Bobrovskaya, O.V., Kovtonogova, I.V. et al. Synthesis and antibacterial activity of 4-aryl-2-hydroxy-4-oxo-2-butenoic (aroylpyruvic) acids N-(4-guanidylsulfonylphenyl)amides. Russ J Gen Chem 85, 833–836 (2015). https://doi.org/10.1134/S1070363215040106

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  • DOI: https://doi.org/10.1134/S1070363215040106

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