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Reaction of 2-(2-oxo-2-arylethylidene)-2,3-dihydropyrimidine-4(1H)-ones with aldehydes

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Abstract

2-(2-Oxo-2-arylethylidene)-2,3-dihydropyrimidine-4(1H)-ones react with aromatic and heteroaromatic aldehydes to form the unsaturated ketones, whereas in the case of 3- and 4-benzaldehydes the corresponding trans-2-styrylpyrimidine-4(3H)-ones were obtained. A possible mechanism of hydrolytic cleavage of the product of condensation of 2-(2-oxo-2-phenylethylidene)-2,3-dihydropyrimidine-4(1H)-one with paraformaldehyde under acid catalysis and mechanochemical activation has been discussed.

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Authors and Affiliations

  1. Bogatskii Physico-Chemical Institute, National Academy of Sciences of Ukraine, Lyustdorfskaya doroga 86, Odessa, 65080, Ukraine

    A. A. Yavolovskii, Yu. E. Ivanov, D. E. Stepanov, S. M. Pluzhnik-Gladyr & G. L. Kamalov

  2. Mechnikov Odessa National University, Odessa, Ukraine

    L. V. Grishchuk & E. I. Bevzyuk

Authors
  1. A. A. Yavolovskii
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  2. L. V. Grishchuk
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  3. E. I. Bevzyuk
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  4. Yu. E. Ivanov
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  5. D. E. Stepanov
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  6. S. M. Pluzhnik-Gladyr
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  7. G. L. Kamalov
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Corresponding author

Correspondence to S. M. Pluzhnik-Gladyr.

Additional information

Original Russian Text © A.A. Yavolovskii, L.V. Grishchuk, E.I. Bevzyuk, Yu.E. Ivanov, D.E. Stepanov, S.M. Pluzhnik-Gladyr, G.L. Kamalov, 2014, published in Zhurnal Obshchei Khimii, 2014, Vol. 84, No. 5, pp. 777–781.

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Yavolovskii, A.A., Grishchuk, L.V., Bevzyuk, E.I. et al. Reaction of 2-(2-oxo-2-arylethylidene)-2,3-dihydropyrimidine-4(1H)-ones with aldehydes. Russ J Gen Chem 84, 869–874 (2014). https://doi.org/10.1134/S1070363214050156

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  • DOI: https://doi.org/10.1134/S1070363214050156

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