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Synthesis, spectroscopic, thermal, free radical scavenging ability, and antitumor activity studies of cobalt(II) metformin complex

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Abstract

New [Co(Mfn-HCl)2(NO3)2] · 6H2O complex has been synthesized and characterized using microanalytical, molar conductance, spectroscopic (IR and UV-Vis), effective magnetic moment, and thermal analyses. The infrared spectroscopic results data received from the comparison between free Mfn · HCl ligand and its cobalt(II) complex proved that Metformin forms complex with cobalt(II) ions as a bidentate ligand through its two imino groups. The antioxidant activity of the Mfn · HCl and Co(II)-2Mfn · HCl complex were evaluated by using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging method. Antitumor activity for Mfn · HCl ligand and its cobalt(II) complex was determined using Ehrlich Ascites carcinoma cell (EACC) line. It has been shown that the Co(II)-Mfn · HCl complex is much more effective as free radical scavenger and has higher antitumor activity than the free Mfn · HCl ligand.

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References

  1. Zhu, M., Lu, L., Yang, P., and Jin, X., Acta Crystallogr. E, 2002, vol. 58, p. 217.

    Article  CAS  Google Scholar 

  2. Meenu, P., J. Phosphorus Sulfur Silicon, 2012, vol. 187(9), p. 1026.

    Article  CAS  Google Scholar 

  3. Spacu, P. and Gheorghiu, C., J. Less Common Met., 1968, vol. 15, p. 331.

    Article  CAS  Google Scholar 

  4. Gheorghiu, C., Z. Anorg. Allg. Chem., 1969, vol. 365, p. 91.

    Article  CAS  Google Scholar 

  5. Spacu, P. and Gheorghiu, C., J. Less Common Met., 1969, vol. 18, p. 117.

    Article  CAS  Google Scholar 

  6. Marchi, A., Marvelli, L., Cattabriga, M., Rossi, R., Neves, M., Bertolasi, V., and Ferretti, V., J. Chem. Soc. Dalton Trans., 1999, p. 1937.

    Google Scholar 

  7. Moghimi, A., Khavassi, H.R., Dashtestani, F., Kordestani, D., Ekram Jafari, A., Maddah, B., and Moosavi, S.M., J. Mol. Struct., 2011, vol. 996, p. 38.

    Article  CAS  Google Scholar 

  8. Rao, N.K. and Annapurna, M.M., Research Papers, 2007, vol. 3, p. 1.

    Google Scholar 

  9. Sandeep, R.N., Nirankar, N.M., Pratibha, P., Ashok, K., and Pitre, K.S., Indian J. Exp. Biol., 1996, vol. 34, p. 81.

    Google Scholar 

  10. Al-Saif, F.A. and Refat, M.S., J. Therm. Anal. Calorim., 2012, vol. 111(3), p. 2079.

    Article  CAS  Google Scholar 

  11. Janjetovic, K., Vucicevic, l., Misirkic, M., Villmanovich, U., Tovilovic, G., Zogovic, S., Bumbasirevic, V., Trajkovic, V., and Trajkovic, L., Eur. J. Pharmacology, 2011, vol. 651, p. 41.

    Article  CAS  Google Scholar 

  12. Correia, S., Carvalho, C., Cantos, M.S., Proenca, T., Nunes, E., Duarte, A.L., Monteiro, B., Seica, R., Oliveira, C.R., and Moreira, P.I., Med. Chem., 2008, vol. 4, p. 358364.

    Article  Google Scholar 

  13. Huang, X., Wullschleger, S., Shpiro, N., McGuire, V.A., Sakamoto, K., Woods, Y.L., McBurnie, W., Fleming, S., and Alessi, D.R., Biochem. J., 2008, vol. 412, p. 211.

    Article  CAS  Google Scholar 

  14. Bukhari, B.S., Memon, S., Mahroof Tahir, M., and Bhanger, M.I., J. Mol. Struct., 2008, vol. 892, p. 39.

    Article  CAS  Google Scholar 

  15. Moridani, M.Y., Pourahmad, J., Bui, H., Siraki, A., and Brien, P.J., Free Radic. Biol. Med., 2003, vol. 34, p. 243.

    Article  CAS  Google Scholar 

  16. Elson, M. and Hass, M.D., Healthy with Nutrition: The Complete Guide to Diet and Nutrition Medicine, Celestial Arts, 2006.

    Google Scholar 

  17. Ramachandran, E., Thomas, S.P., Poornima, P., Kalaivani, P., Prabhakaran, R., Padma, V.V., and Natarajan, K., Eur. J. Med. Chem., 2012, vol. 50, p. 405.

    Article  CAS  Google Scholar 

  18. Selwood, P.F., Magnetochemistry, 2nd ed., New York: Wiley Interscience, 1956.

    Google Scholar 

  19. Biois, M.S., Nature, 2000, vol. 26, p. 1199.

    Google Scholar 

  20. Bennett, J.M., Catovsky, D., Danniel, M.T., Galton, D.A.G., Graanlink, H.R., and Sultan, C., British J. Hematology, 1976, vol. 33, p. 451.

    Article  CAS  Google Scholar 

  21. UmaDevi, P., Soloman, F.E., and Sharada, A.C., Pharm. Biol., 1999, vol. 73, p. 231.

    Google Scholar 

  22. Refat, M.S., Spectrochim Acta (A), 2007, vol. 68(5), p. 1393.

    Article  CAS  Google Scholar 

  23. Bellamy, L.J., The Infrared Spectra of Complex Molecules, 3 ed., London: Chapman and Hall; 1975.

    Book  Google Scholar 

  24. Socrates, G., Infrared Characteristic Group Frequencies, 1 ed., New York: Wiley, 1980.

    Google Scholar 

  25. Shanmugam, R. and Sathyanarayana, D.N., Spectrochim Acta (A), 1984, vol. 40(8), p. 757.

    Article  Google Scholar 

  26. Sharma, A., Gupta, V.P., and Virdi, A., Indian J. Pure Appl. Phys., 2004, vol. 42(4), p. 251.

    CAS  Google Scholar 

  27. Dalton, F., Hill, R.D., and Meakins, G.D., J. Chem. Soc., 1960, vol. 590, p. 2927.

    Article  Google Scholar 

  28. Nakamoto, K., Infrared and Raman Spectra of Inorganic and Coordination Compound, New York: Wiley, 1978.

    Google Scholar 

  29. Ross, S.D., Inorganic Infrared and Raman Spectra, Mc Graw Hill, London, 1972.

    Google Scholar 

  30. Singh, H.L. and Varshney, A.K., Bioinorg. Chem. Appl., 2006, vol. 2006, p. 1.

    Article  CAS  Google Scholar 

  31. Ozturk, O.F., Sekerci, M., and Ozdemir, E., Russ. J. Coord. Chem., 2005, vol. 31(9), p. 687.

    Article  CAS  Google Scholar 

  32. Ozturk, O.F., Sekerci, M., and Ozdemir, E., Russ. J. Gen. Chem., 2006, vol. 76, p. 33.

    Article  CAS  Google Scholar 

  33. Allan, J.R., Baird, N.D., and Kassyk, A.L., J. Therm. Anal., 1979, vol. 16(1), p. 79.

    Article  CAS  Google Scholar 

  34. Ray, S., Konar, S., Jana, A., Jana, S., Patra, A., Chatterjee, S., Golen, J.A., Rheingold, A.L., Mandal, S.S., and Kar, S.K., Polyhedron, 2012, vol. 33(1), p. 82.

    Article  CAS  Google Scholar 

  35. Girasolo, M.A., Canfora, L., Sabatino, P., Schillaci, D., Foresti, E., Rubino, S., Ruisi, G., and Stocco, G., J. Inorg. Biochem., 2012, vol. 106(1), p. 156.

    Article  CAS  Google Scholar 

  36. Quan, C.X., Bin, L.H., and Bang, G.G., Mater. Chem. Phys., 2005, vol. 91, p. 317.

    Article  CAS  Google Scholar 

  37. Coats, W. and Redfern, J.P., Nature, 1964, vol. 201, p. 68.

    Article  CAS  Google Scholar 

  38. Horowitz, H.H. and Metzger, G., Anal. Chem., 1963, vol. 35, p. 1464.

    Article  CAS  Google Scholar 

  39. Mahfouz, R.M., Monshi, M.A., Alshehri, S.M., El-Salam, N.A., and Zaid, A.M.A., Synth. React. Inorg. Met.-Org.. Chem., 2001, vol. 31(10), p. 1873.

    Article  CAS  Google Scholar 

  40. Frost, A.A. and Pearson, R.G., Kinetics and Mechanism, New York: Wiley, 1961.

    Google Scholar 

  41. Hamada, M.M., Shallaby, A.H.M., El-Shafai, O., and El-Asmy, A.A., Trans. Met. Chem., 2006, vol. 31, p. 522.

    Article  CAS  Google Scholar 

  42. Sharma, P.K., Sen, A.K., and Dubey, S.N., Indian J. Chem., 1994, vol. 6, p. 291.

    Google Scholar 

  43. El-Metwally, N. and El-Asmy, A.A., J. Coord. Chem., 2006, vol. 59(14), p. 1591.

    Article  CAS  Google Scholar 

  44. Xinquan, X. and Anbang, D., Pure Appl. Chem., 1988, vol. 60(8), p. 1217.

    Article  Google Scholar 

  45. Sagar, B., Kedare, R., and Singh, P., J. Food Sci Technol., 2011, vol. 48(4), p. 412.

    Article  CAS  Google Scholar 

  46. Shimada, K., Fujikama, K., Yahara, K., and Nakamura, T., J. Agricultural Food Chem., 1992, vol. 40, p. 945.

    Article  CAS  Google Scholar 

  47. Afanas’ev, I. B., Ostrakhovitch, E. A., Mikhal’chik, E.V., Ibragimova, G.A., and Korkina, L.G., Biochem. Pharmacol., 2001, vol. 61, p. 677.

    Article  Google Scholar 

  48. Hui-Lu, W., Jing-Kum, Y., Ying, B., Fei, J., Bin, L., and Fan, K., Trans. Met. Chem., 2011, vol. 36(8), p. 819.

    Article  CAS  Google Scholar 

  49. Simmons, R.A., Free Radical Biol. Med., 2006, vol. 40, p. 917.

    Article  CAS  Google Scholar 

  50. Robertson, R.P. and Harmon, J.S., FEBS Lett., 2007, vol. 581, p. 3743.

    Article  CAS  Google Scholar 

  51. Kono, Y. and Fridovich, I., J. Biol. Chem., 1982, vol. 257, p. 5751.

    CAS  Google Scholar 

  52. Watson, J., Open Biol., 2013, vol. 3, p. 1.

    Article  CAS  Google Scholar 

  53. Bost, F., Ben-Sahra, I., and Tanti, J., Cancer Prev. Res., 2012, vol. 5(4), p. 503.

    Article  CAS  Google Scholar 

  54. Tomic, T., Botton, T., Cerezo, M., Robert, G., and Luciano, F., Cell Death Dis., 2011, vol. 2, p. 199.

    Article  CAS  Google Scholar 

  55. Gallagher, E. and Leroith, D., Endocrinology, 2011, vol. 152, p. 2546.

    Article  CAS  Google Scholar 

  56. Jungwirth, U., Kowol, R.C., Keppler, B.K., Hartinger, G.C., Berger, W., and Heffeter, P., Antioxid. Redox Signaling, 2011, vol. 60, p. 1.

    Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Taif University, 888, Taif, Kingdom Saudi Arabia

    Moamen S. Refat & Mohamed I. Kobeasy

  2. Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt

    Moamen S. Refat

  3. Department of Biochemistry, Faculty of Agriculture, Cairo University, Cairo, Egypt

    Mohamed I. Kobeasy

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  1. Moamen S. Refat
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  2. Mohamed I. Kobeasy
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Correspondence to Moamen S. Refat.

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Refat, M.S., Kobeasy, M.I. Synthesis, spectroscopic, thermal, free radical scavenging ability, and antitumor activity studies of cobalt(II) metformin complex. Russ J Gen Chem 84, 767–774 (2014). https://doi.org/10.1134/S1070363214040288

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  • DOI: https://doi.org/10.1134/S1070363214040288

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