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Cyclocondensation of methyl 2-(1,3-benzothiazol-2-ylimino)-3,3,3-trifluoropropionate with C,N-binucleophiles

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Abstract

Reactions of methyl 2-(1,3-benzothiazol-2-ylimino)-3,3,3-trifluoropropionate with 1,3-C,N-binucleophiles, methyl 2-aminobut-2-enoate, 2-aminobut-2-enenitrile and N-substituted 6-aminouracils and 3-aminocyclohex-2-en-1-ones, led to the formation of trifluoromethyl-substituted heterocycles, dihydro-1H-pyrroles, hexahydro-1H-pyrrolo[2,3-d]pyrimidine-2,4,6-triones, and hexahydro-1H-indole-2,4-diones.

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Authors and Affiliations

  1. Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow oblast, 142432, Russia

    V. B. Sokolov & A. Yu. Aksinenko

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  1. V. B. Sokolov
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  2. A. Yu. Aksinenko
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Correspondence to A. Yu. Aksinenko.

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Original Russian Text © V.B. Sokolov, A.Yu. Aksinenko, 2011, published in Zhurnal Obshchei Khimii, 2011, Vol. 81, No. 5, pp. 847–849.

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Sokolov, V.B., Aksinenko, A.Y. Cyclocondensation of methyl 2-(1,3-benzothiazol-2-ylimino)-3,3,3-trifluoropropionate with C,N-binucleophiles. Russ J Gen Chem 81, 934–936 (2011). https://doi.org/10.1134/S1070363211050161

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  • DOI: https://doi.org/10.1134/S1070363211050161

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