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Synthesis, structure and properties of complex compounds of cobalt, nickel, copper and zinc with 2-formylpyridine semicarbazone

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Abstract

2-Formylpyridine semicarbazone L reacts with cobalt, nickel, copper and zinc chlorides, nitrates and perchlorites to form coordination compounds of compositions ML2X2·nH2O (M=Co, Ni, Cu, Zn; X = Cl, NO3, ClO4; L = NC5H4-CH=N-NH-C(O)-NH2; n = 0, 1) and CuLX2·nH2O (X = Cl, Br, NO3; n = 0−0.5). Complex CuL(NO3)2 has polynuclear, CuLX2·0.5H2O (X = Cl, Br), binuclear, and other compounds, mononuclear structures. Azomethine L behaves in them as tridental N,N,O-ligand. Thermolysis of these complexes proceeds through such stages as dehydration (80–95°C), deactivation (145–155°C) and complete theral degradation (170–590°C). Complexes CuLX2·nH2O (X = Cl, NO3; n = 0−0.5) were established to inhibit in vitro the growth and reproduction of 100% of cancer cells of human mieloid leukaemia HL-60 at 10−4 M concentration. At 10−5 M concentration they inhibit only 10% of cells, and at 10−6 M concentration they do not possess anticancer activity.

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Authors and Affiliations

  1. Moldavian State University, ul. Mateevicha 60, Kishinev, 2009, Moldova

    A. P. Gulya, N. N. Bairak & V. I. Tsapkov

  2. Al.I. Cuza University, Iasi, Romania

    D. Gynzhu

  3. Centre Hospitalier Universitaire de Quebec (CHUQ), Sainte-Foy, Quebec, Canada

    D. Poirier

Authors
  1. A. P. Gulya
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  2. D. Gynzhu
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  3. N. N. Bairak
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  4. D. Poirier
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  5. V. I. Tsapkov
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Correspondence to A. P. Gulya.

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Original Russian Text © A.P. Gulya, D. Gynzhu, N.N. Bairak, D. Poirier, V.I. Tsapkov, 2009, published in Zhurnal Obshchei Khimii, 2009, Vol. 79, No. 7, pp. 1142–1146.

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Gulya, A.P., Gynzhu, D., Bairak, N.N. et al. Synthesis, structure and properties of complex compounds of cobalt, nickel, copper and zinc with 2-formylpyridine semicarbazone. Russ J Gen Chem 79, 1499–1503 (2009). https://doi.org/10.1134/S1070363209070160

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  • DOI: https://doi.org/10.1134/S1070363209070160

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