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Coordination compounds of cobalt, nickel, copper, and zinc with N 1,N 2-bis(pyridin-2-ylmethylidene)benzene-1,2-diamine and its derivatives

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Abstract

o-Phenylenediamine reacts with 2-formyl-, 2-acetyl-, or 2-benzoylpyridine in ethanol in the presence of cobalt, nickel, copper, or zinc chlorides to form monomeric complexes ML1–3Cl2·nH2O {M = Co, Ni, Cu, Zn; L1 = N 1,N 2-bis(pyridin-2-ymethylidene)benzene-1,2-diamine, L2 = N 1,N 2-bis(pyridin-2-ylethylidene) benzene-1,2-diamine, L3 = N 1,N 2-bis[phenyl(pyridin-2-yl)methylidene]benzene-1,2-diamine; n = 0–3}. The condensation products (L1–L3) act in the complexes as tetradentate N,N,N,N-ligands. Thermolysis of the complexes occurs in two stages: dehydration (70–95°C) and complete degradation (320–450°C). At concentrations of 10−5–10−7 M, the complexes inhibit in vitro growth and proliferation of HL-60 human promyelocytic leukemia cells.

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Authors and Affiliations

  1. Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

    E. Pahontu

  2. State University of Moldova, A. Mateevici st. 60, Chişinău, 2009, Moldova

    A. P. Gulea & V. I. Tsapkov

  3. Laval University, Québec, Canada

    D. Poirier

Authors
  1. E. Pahontu
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  2. A. P. Gulea
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  3. D. Poirier
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  4. V. I. Tsapkov
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Corresponding author

Correspondence to A. P. Gulea.

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Original Russian Text © E. Pahontu, A.P. Gulea, D. Poirier, V.I. Tsapkov, 2014, published in Zhurnal Obshchei Khimii, 2014, Vol. 84, No. 9, pp. 1530–1533.

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Pahontu, E., Gulea, A.P., Poirier, D. et al. Coordination compounds of cobalt, nickel, copper, and zinc with N 1,N 2-bis(pyridin-2-ylmethylidene)benzene-1,2-diamine and its derivatives. Russ J Gen Chem 84, 1767–1770 (2014). https://doi.org/10.1134/S1070363214090217

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  • DOI: https://doi.org/10.1134/S1070363214090217

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